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Social networking thesis papers

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Blogging is the New Persuasive Essay. Social Networking! As an English teacher, I#8217;ve had numerous conversations with college professors who lament the writing skills of their first year students. But not all writing. Most students are capable of solid expository writing. It#8217;s their skill with persuasive writing that#8217;s the problem. Specifically, they#8217;re weak at writing a thesis statement that can be argued. I spend three years teaching my high school students how to write a persuasive essay. For many students, it takes that long. (And I#8217;m lucky to have them that long in my school.) Part of the problem is ncea level creative writing, that our current school systems #8212; and not just in social networking thesis, Canada #8212; aren#8217;t great at producing independent thinkers. Without this ability, it#8217;s hard to create a great thesis statement, anticipate the hormone research, arguments against it, and then compose your own argument in light of networking papers what you understand about the baker thesis, pros and social networking thesis papers cons of an issue. So for three years, I write for sheridan them, and with them.

We talk about thesis, opening paragraphs, and they learn how to sheridan machine, write them with their thesis statement either as the networking, first or last sentence. (The latter requires more skill.) They learn to uni, use transition words, embed quotations to support their argument, consider the advantages of active vs. passive voice, vary their sentences, and many other skills, all in social thesis papers, the hope of creating a strong argument. The truth is lately I#8217;ve come to question the our daughters ourselves, point of much of this. Does the average person, once they leave school, spend a lot of time composing academic essays? Is this the best way for our students to show their learning? In some places, the academic 5 paragraph essay is hailed as the Holy Grail of social thesis papers non-fiction writing achievement.

Yet even if a student can become a great persuasive essay writer, they#8217;re still only semi-literate, at least according to the definition of 21st Century Literacies. While traditional essay writing may not help alleviate this situation, I think blogging can. Here#8217;s the problem; Blogging is an entirely different beast. And one of the things I#8217;ve learned about my students is that they don#8217;t necessarily transfer a skill they#8217;ve learned in one area to thesis uni, another without difficulty, or even prompting. For one, the paragraphing is social networking thesis, different. The large, solid paragraphs of prose that can be found in a typical persuasive essay, can feel arduous and 1 english cumbersome to all but the social networking papers, most determined reader. Instead, blog paragraphs tend to be shorter. It allows the politics thesis, piece to feel fluid and speeds up the rate at which your reader reads (often through the glare of a computer monitor or on a phone or tablet screen). And while the effective blogger still uses transition words, as many aren#8217;t necessary to provide the piece with a feeling of social networking papers fluidity and baker thesis machine coherence. Networking Thesis! Sometimes a paragraph is plant, one simple sentence, used for emphasis. Networking Papers! Another thing is the thesis statement.

Its placement, in a blog, is up for grabs. Did you catch where mine is? Actually, I haven#8217;t written it yet. Huh?! Blogging also requires a different voice. The way I blog isn#8217;t quite how I talk, but it#8217;s no where close to how I write a formal essay. Furthermore, the hormone research, voice used in blogging needs to be rich, sharp and distinct, to gain an audience.

And while some may argue that academic writing could stand to have a bit more colour and flair, I#8217;m not sure that#8217;s currently the accepted norm (although I wish it was). Networking Thesis Papers! In a formal essay, I would never use a sentence fragment. Ever. In a blog, it provides emphasis. Nor would I use slang in an essay. But here? Yep. In one of baylor university my posts, I double-dog dared my readers. Could you imagine double-dog daring anyone in an academic essay? If you try it, let me know the social networking thesis, result. Another thing that changes is providing your reader with evidence to support your points.

In teaching the typical formal essay, I show my students how to quote directly, indirectly, and baylor admissions essay using individual words. Blogs still use direct quotes, but an indirect quote can be as simple as a vague mention and a link. I think blogging is the new persuasive essay -my thesis, finally. Social Networking Thesis Papers! Truth is, I love writing essays. There#8217;s something satisfying about essay, rendering the chaos of thoughts into thesis, an elegant form.

But I love blogging more. It feels like playing. I also find it more useful. While our students will need to baylor university admissions essay, know how to write essays to get through university, many won#8217;t use it after that, unless they remain in academia. I think writing and persuasive thinking skills are important.

However, I question the current products we require of social networking thesis students as proof of their learning. Most of the essays written by our students likely end up in the garbage or the computer trash can. In Indian Uni! And most are for an audience of social papers one. Blogging has the machine, potential to reach and influence many. Furthermore, it has greater potential for being a life-long skill. And isn#8217;t that our goal in education? People from all walks and professions blog for the purpose of teaching, creating, and informing.

A number of my recent Masters courses didn#8217;t require papers; instead, they required blogging. Why? Because blogging is the new persuasive essay. If we#8217;re trying to social thesis, prepare our students to think critically and argue well, they need to politics thesis in indian uni, be able to thesis, blog. It allows for essays on injustice interaction. It allows for ideas to be tested. Networking Thesis! And the thesis machine, best posts anywhere in cyberspace tend to have a point that can be argued.

I think blogging across the curriculum, not just in Language Arts, allows for both formative and summative assessment. Blogs allow us to see the progression in the development of both thinking and writing. It may actually take more talent and skill to create an interesting persuasive post (or series of posts) on the French Revolution than a traditional essay. Papers! We need to teach blogging as a skill. Students definitely need to understand how and essays on injustice in america why the mechanics (and style) of blogging are different. Grade One blogger (Kathy Cassidy) The solution? Blogging needs to start earlier, much earlier. I read recently of a kindergarten teacher who blogs with her students. Great idea.

There#8217;s a teacher in social networking thesis, my division who does amazing things with her grade one class. I#8217;m not proposing that you need to do things radically different. Teach whatever you teach for Language Arts, or other subjects, but include a blog component. So if you#8217;re teaching sentence structure, teach your students to create complete sentences while blogging. Blogs, like traditional writing, need great structure. If you#8217;re focusing on capitalization or punctuation, transfer this skill to blog writing as well. If you#8217;re teaching paragraph structure, teach students the ourselves, paragraph structure required for traditional essays and that for blogs. They#8217;re different.

Explain why. Social Networking Thesis! It#8217;s likely they won#8217;t be good at our daughters ourselves it at social thesis papers first. But there is merit to in america, the quote, #8220;Anything worth doing, is worth doing badly.#8221; A middle years teacher at my school used to stress out when we talked about social papers, student writing. She wanted to know if she was teaching them enough. My reply: #8220;All I need them to do is write solid paragraphs.

If they can do that, I can teach them all kinds of our daughters ourselves things.#8221; Really, everything I teach is either an social networking thesis papers addition to, or a subtraction from, a solid paragraph. My work builds on her work. I don#8217;t need her to our daughters essay, teach what I teach. That#8217;s my job. Social Networking Papers! But without her previous work, mine becomes much more difficult. Machine! The same is true with blogging.

Starting from scratch with blogging in grade 10 isn#8217;t impossible. But we could do so much more if they already had the basics. In order to social papers, write well, you need to sheridan baker, write a lot. Thesis Papers! If you don#8217;t currently teach your students to blog, please start. Our students need you to. And if you already teach your students to blog, keep it up. Because blogging is an important 21st century skill.

It#8217;s the new persuasive essay. Latest posts by Shelley Wright (see all) Are You Ready to Join the baylor, Slow Education Movement? - August 26, 2014 Academic Teaching Doesn#039;t Prepare Students for Life - November 7, 2013 Start with Why: The power of networking thesis papers student-driven learning - June 21, 2013. Shelley, I love this!! I started using Kidblog with my 3rd graders last year, and looped up with them this year. Their 4th grade blogs were much improved, and I enjoyed watching them begin to develop their own blogging #8220;style#8221;. Ncea Level 1 English Creative Writing Exemplars! I did get some negative comments from both parents and other teachers that this was not #8220;writing.#8221; They felt it was too casual and too unstructured. (I#8217;ll admit, the social, Grammar Nazi in sheridan baker machine, me gasped when I saw sentences in your blog beginning with #8220;and.#8221;) In lieu of a research paper this year, my students created Glogs that contained text boxes with information (well written paragraphs), but also allowed links, images, and a personal design. They loved it!

I think you are absolutely right that students need to understand the difference. There are times when more formal writing is necessary, so I#8217;m sure to teach it and require it on certain assignments. Networking Thesis! I love it though that blogging enables them to ourselves essay, discover their writing style and voice. Blogging does feel like playing, and kids love to play. If blogging makes them love to write, I think we#8217;re fools not to encourage it! Thanks for a great post! Thanks, Patti.

I think, unfortunately, there are many people who don#8217;t see the thesis papers, point or value of our daughters ourselves blogging. My students, for the most part, have always enjoyed it. What I disgree with is teaching only social networking papers academic writing in schools. I think there are many formats our students need to learn #8212; blogging being only one. I think there#8217;s value to essays, academic writing, but most of our kids aren#8217;t going to become academics, and social thesis that#8217;s a good thing #128578; Throughout high school I was taught that you couldn#8217;t start a sentence with because or and. Then I went to university and was told you could.

Boy was that a shock! When I was in college I was taught not to use the first person pronoun in plant research paper, my writing, EVER. Then I went to social networking thesis, graduate school (Harvard) and everybody did it! Shocked again. Patti, thanks for posting links to keep me updated. I would love to try this with my kids this year but I need to be able to in indian, do it too! Great blog post on writing. Networking Papers! I#8217;m constantly trying to find more and various ways to have students write in my Grade 8 US History class. Part of my task is to prepare them for the persuasive essay format on our daughters ourselves essay the ACT and the MME (Michigan Merit Exam). Your blog was helpful.

Thanks. As I started reading your blog I was thinking, I teach some of thesis papers those things to my fourth graders. However, it seems after fourth grade the writing drops to a minimal until it is tested again in 7th grade. (Or at least that#8217;s the way it appears to me). I introduced blogging to my students 2 years ago and they loved it! It inspired more students to write as they had the global audience (which I think is a big draw). This year my students enjoyed it as well. However, I never really thought about the difference between writing in baylor admissions, a blog and writing formally but will be discussing it with this year#8217;s class. Really, sharing your writing via a blog is exciting especially when you receive comments. I#8217;ll be sharing your post around as I would love to get more teachers to social networking thesis papers, see the importance of blogging! Thanks for sharing. Thanks, Nancy!

Students having an authentic audience is important. That#8217;s why we normally write. We have something to communicate to someone, and we choose the best medium for it, as well as an appropriate style. Politics! I wonder what Language Arts would become if we thought of it as a communications class? This rings true for me in every paragraph. Social Networking Thesis! I have recently begun a blogging project with some very able Year 10 students (please have a look at my blog!) and there has been quite a lot of thesis in indian uni resistance along the lines of #8220;What#8217;s the point?#8221; Your emphasis on moving with the times instead of stubbornly sticking to tradition strikes a resonant chord with my own teaching.

Please keep this up, you have just made my day! I think, sometimes, kids don#8217;t see the point. They#8217;re not really used to social networking, having any of their work having a point or a real audience. I found that once my students got used to doing work that was authentic and meaningful, the #8220;what#8217;s the point?#8221; stopped. Sheridan Baker Thesis Machine! While I agree with much of the thesis, fine print of ncea creative writing your argument, specifically notions of voice and your ideas about what good writing should feel/sound like, it seems to me that your premise is false. Thesis Papers! The blog/ persuasive essay duality is a false dichotomy. Certainly, students should consider form and purpose when they write, but they shouldn#8217;t learn, and we shouldn#8217;t teach, that blogs are all short paragraphs richly voiced. Admissions Essay! Great essays, and great blogs, can also be written with long and well voiced paragraphs. I think we do our students and each other a disservice when we promote, teach, or otherwise create these sorts of false either/ors. Social Networking Thesis! (The same is true of the grammar policing we do often at school, evidenced by Patti#8217;s mention of using a conjunction at the beginning of a sentence in thesis uni, a comment above.) Good writing works. We can explore and social networking thesis papers explain why it works, but it#8217;s never as simple as following all the rules for the particular container or mode or genre.

It#8217;s in the playful fiddling with all of those that good writing emerges. 1 English Writing Exemplars! Thanks for social networking engaging my brain here. I agree that good writing is good writing, and I don#8217;t believe that blogs or the persuasive essay is an either/or thing. I think both should happen, but where I currently work, it doesn#8217;t. I see too often the academic essay hailed as the most essential skill a student can develop. I think the uni, reason behind it is laudable;students should be able to argue their point of view. But too often there is no authentic audience or task attached to it, and social thesis papers it becomes for our daughters students another hoop to jump to get the #8220;A#8221;. I think the thing that bothers me the most about it is the heirarchy that develops around kids who are considered #8220;academic#8221;, those who can write the essay, and those who are not. This is social networking thesis, bad for kids and teachers, so lately I#8217;ve come to ask why are we doing all of this, and aren#8217;t there more important skills they can learn? I#8217;m not sure I agree with you on the long paragraphs in a blog.

I think you have to be a great writer to pull it off, and I haven#8217;t read a lot of those. But that#8217;s also what I tell my students. I don#8217;t tell them they can#8217;t do it. Instead, I tell them they have to be a strong writer to make it work. And for some of them, that#8217;s the challenge they need. They want to see if they can do it because they desire to be a strong writer. Essays On Injustice In America! I teach composition at the community college level and trying to break the 5 paragraph habit is one of the first things I work with them on. That and the act of social thesis papers critical thinking and then writing down those critical thoughts. I think a blog is a great way to show students there is more than one way to express themselves. I am also a firm believer in sheridan baker machine, blogging with my students! I have used Kidblog for the past two years with my 5th graders., and it is an amazing tool to create motivated writers! #8220;Write On!: Why I Love Kidblog!#8221; I like and appreciate the fact that you made your points and also demonstrated them.

I agree that paragraphs must be short for continuity, ease of flow and for referring back. I would add that you can include pics, vids, links, graphs, etc. to thesis papers, add flair and information to your persuasive blog/ opinion post. Also, when I teach blogs in Writers Craft (gr 12) I make them aware that their audience is potentially the rest of the world. Daunting. And it makes them want to admissions essay, proofread a lot more and to consider the attractiveness of their blog and their writing style. Think about thesis, this: It is incredible that we as teachers can teach writing in such a way that the teacher isn#8217;t the only one whoever sees their writing. This is a huge shift and speaks to the way s of the world of the next generation. Until someone comes up with an #8220;The Elements of thesis in indian Blog Style#8221; that Bud and Tom and Shelley and others agree deserves respect, we don#8217;t have a real standard to go by. Shelley describes what makes sense to her #8212; Bud Hunt, a respected National Writing Project proponent demurs. No doubt others do as well. Tom says that #8220;paragraphs must be short for continuity, ease of flow and for referring back.#8221; I#8217;m not sure it is a #8220;must#8221; but in nearly a decade of social editing group blogs and online diaries with a hundred or more educators, my sense is that this is *generally* a good rule of university admissions essay thumb.

It seems to papers, me that the blog author needs a very good reason to publish long paragraphs that will appear on a screen at an unpredictable size and width (density) and be viewed by in indian all kinds of social eyes with all kinds of vision challenges. Certainly the writing will need to essays on injustice, be compelling! I don#8217;t know the history of the long paragraph (chances are I#8217;ll be researching it this week to satisfy my demon), but I#8217;m guessing that long paragraphs are the residual of social networking papers several thousand years of university admissions writing on smooth flat rocks and hides and papyrus and hard-to-get pulp paper printed a sheet at social a time. Humans crammed as much as they could into baylor essay, the scarce space. Nothing scarce about cyberspace. Why not change the social networking thesis papers, rules? Nostalgia for writing styles is okay I certainly have some myself.

But nostalgia is not a good basis for contemporary rulemaking. Here#8217;s an baylor university excellent way to create an authentic audience for your students! #8220;Quadblogging:Creating a Global Connection!#8221; Very interesting food for thought. To be sure, blogging provides a more authentic audience, something that is sorely needed! I also agree that when it comes to writing, there is no #8220;form#8221; with blogs. The issue is that students, and the rest of us, must realize that when something is written such as a persuasive essay, there should be some points of reference. What I find is, that due to a society that cannot focus but for short periods of time, thoughts are expressed based on unfounded suppositions. Papers! Students have to politics in indian uni, realize that more formal, traditional writing, gives them practice on conventions such as writing full words, sentences, etc. and some other standards of grammar. Not old fashioned, but keeps things from social networking papers becoming a free-for-all.

I think blogging should provide students with the plant hormone, opportunity to practice using conventions and form #8212; in an authentic context. I don#8217;t think that only formal writing can, or should, do this. I think one of the things we often forget when teaching writing is that we#8217;re teaching them to communicate, and that in writing there is a #8220;code#8221; of communication that has developed over the centuries between reader and writer. There are reasons we write and punctuate as we do. Instead, we often teach rules, rather than the intimate relationship between reader and writer. I think the latter is networking papers, much more persuasive for students and creates better thinkers and writers in the long run. Essays On Injustice! Thank you for networking thesis papers that article. Baylor University Admissions Essay! I#8217;ve been perusing articles on education for about three hours now, and I am glad I came across yours.(catching up on my education articles) Not only do we need to move toward the social networking, realities of our students experiences, but there is room for interpretation on how we teach to it.

We can argue all day long on sheridan the who#8217;s and how#8217;s , but at the end of the day is your writing effective. In whatever form or voice you choose. Networking Papers! peoples response to your blog will be the best indicator. Essays On Injustice! Now, how about social, those poorly constructed e-mails. Would someone please blog on baylor admissions the voice and content of e-mails. If I#8217;m not written into networking thesis, your will, I#8217;m not reading a long drawn out ncea level writing exemplars e-mail. Peter, no one is suggesting that blogging should become a #8216;free-for all#8221;, it#8217;s all about creating enthusiasm for longer pieces of writing that create and papers sustain a point of view. Of course we should insist on standard English, but we can do that when setting up the in america, success criteria for blogging just as we would for a formal essay. If blogging gets students to social thesis, engage with and develop their process of writing, I#8217;m all for it, especially if it helps students understand that they may express themselves in on injustice in america, writing through a variety of structures.

As a high school teacher I spend an enormous amount of time and energy trying to thesis papers, convince students that not every idea they have needs to be one that can be expressed in five paragraphs. I do worry, however, that the informality of blogs may encourage vague and formless expression of feelings and suppositions. Though the academic essay is only one mode of written expression it does teach students important skills that transfer to 1 english exemplars, other modes: the structuring of social networking thesis ideas, the presentation and rigorous analysis of evidence, the baker thesis, effects of sentence structure and voice on meaning, to name but a few. Networking Papers! Of course, having students write blogs can also teach them these skills if their blogs are held to certain standards. Ncea Exemplars! The five-paragraph essay may be some dirty bathwater that needs to be tossed, but let#8217;s make sure to social thesis, save the baby, the hallmarks of good writing. I absolutely agree that blogging is an excellent platform for in indian writing and thesis provides the plant, with an authentic audience. I recently attended the ISTE conference and attended a session on establishing connections through blogging presented by Lisa Parisi Brian Crosby. Your blog just reaffirms everything that I took away from this session. Social Networking Papers! Lisa and Brian#8217;s students#8217; writing is truly amazing because, as you mentioned, they have the opportunity to use their own voice to politics thesis in indian uni, take on issues that matter to social thesis papers, them, then when they receive responses to their posts, they are further inspired to write even more. I have the opportunity to coordinate a Teaching American History Grant,, primarily targeted for fifth grade teachers who lay the foundations of American History in their instructional program. One of our grant goals is to essays in america, utilize Web 2.0 technology as an instructional and collaboration tool.

This past year the teachers created their own blogs and networking papers have been utilizing them primarily as a means of communicating/collaborating with each other. The goal for this next year is to have each of the teachers create a blog in hormone, their classroom (or utilize one they have already created) so that students can utilize this platform for writing, with the goal of having others responding to their blogs. Since persuasive writing is social, one of the types of 1 english exemplars writing taught in fifth grade, I believe there will be several opportunities for social networking papers the students to utilize these persuasive writing techniques in their blogs. I hope you enjoyed ISTE this week I remember coming back from my first one quite overwhelmed! There are no large conferences like that in Ontario and it took me a while to unpack all that I learned. Although I have only been blogging for 6 years, I#8217;ve noticed big changes. Essays In America! Blogs or #8216;weblogs#8217; used to be places where folks shared their travels and learning on the web so that others could follow their links and have some understanding of where they received inspiration, new connections or knowledge. Now, you#8217;re lucky to have any links at all shared, and if they are, they are often links back to social networking thesis papers, the writer#8217;s own work! Don#8217;t get me wrong, I love that blogs give students an authentic audience (especially since persuasive writing is a part of our curriculum here in Ontario as early as the plant, primary grades) and I#8217;m not a #8216;purist#8217; about them. I have been using and thesis promoting blogging as a part of baylor university admissions balanced literacy since 2006 and believe they can serve many purposes. I just hope that we do let blogs stand apart from some of our traditional forms of writing so that we aren#8217;t trying to social networking papers, do old school things with new tools.

Many unread and discarded blogs exist because teachers jump onto level exemplars, the blogging bandwagon without scaffolding students to real conversations and authentic purposes for writing. Thanks for bringing up some important conversations here. #128578; I completely agree with what you#8217;ve said, especially your point, #8220;Many unread and discarded blogs exist because teachers jump onto the blogging bandwagon without scaffolding students to real conversations and authentic purposes for writing.#8221; I think this is one of those #8220;21st C. skills#8221; that students need. What does it mean to speak and blog authentically? This will be an especially difficult thing for many high school students to answer since they#8217;ve often had few authentic writing experiences in their academic career. But this ia an important discussion! This is great! I worked with 4th and5th graders this past year on blogging. They did an amazing job! Really only thesis since Jan#8230;came so far. Thanks for this thinking! I think writing for hormone research paper more than an audience of 1 changed their effort, energy and enthusiasm!

It#8217;s amazing what kids can do in such a short time. Thanks for sharing! I think Wright brings up a lot of social networking thesis good points about blogging in this article. Ncea Creative Writing Exemplars! I remember writing persuasive essays and feeling stuck to pick a topic. When I did settle on one it felt so typical of a persuasive argument. We are pushing more and more for authentic practice and papers work from students and blogging is an excellent way to practice naturally. There are blogs about everything under the sun that you could allow students to use in level 1 english, order to start with and practice blogging. Networking Thesis! A teacher could then create a class blog and post: Who has the best blog in the class? Hook, line, and sink her!

What better way to baker thesis machine, get kids into it then going right to what they are passionate about. I could only imagine how long that blog would be and the many mini-lessons it could contain. Some trouble I experienced with persuasive writing was creating the opposing sides arguments. Through blogging students will actually have those arguments given and then will have to decide which are viable and should be included or addressed in their own writing. Blogs exist on every topic, even topics that may not be recognizably controversial. Thesis Papers! This is another reason why blogging to teach persuasive writing is beneficial to students. Blogs are less intimidating because they are short bits of information and the reader has preference over admissions essay which ones to give more attention to and which to ignore.

I would imagine blogging would lead to social networking papers, critical thinking because you are concisely trying to make your point. No one wants to university admissions, read a long blog post. That#8217;s part of why people blog in the first place. Blogging is also able to social networking thesis, reach far more people and cause action than an academic essay whose audience is far less accessible. MyCustomWritings.com essays have absolutely no plagiarism whatsoever! Our team of professional writers are not only dependable but provide plagiarism-free papers.

To put you at ease, we attach a plagiarism report to each and every order. Therefore, once you place an order with us, rest assured that you will receive a creative, well-researched and our daughters documented essay, term paper, coursework or dissertation. We are 100% genuine! Hey Shelly, I think this is an excellent blog, I really enjoy your outlook on social networking thesis papers education and your core beliefs that teachers need to move forward with the 21st century. I#8217;m a Grade 10 English teacher in the Middle East and I was wondering if you had any suggestions for baylor university essay websites that would be ideal for social thesis getting my students excited about plant hormone research, blogging? I think it#8217;s really important when students first start blogging that they research and social thesis write about politics thesis, things that really matter to social networking thesis papers, them. It might be one way to infuse student choice into the classroom. Here are some resources that you might find helpful to get started: And this link has pretty much everything you could ever need!

Hope this helps! Thank you so much for ncea 1 english creative exemplars your blog post it was a gift that Carol Mayne sent me as I have had a huge investment in blogging with my classes. I#8217;m constantly learning and revising the process, but love how it has transformed my class and the writing (and reading) my kids are doing. I look forward to more posts by you! Pamela Hunnisett (Calgary) I just wanted to let you know that this post inspired me in the beginning of the year, and my students are now blogging on an (almost) weekly basis. It#8217;s transforming their writing and my classroom. Thank you! That#8217;s terrific to hear! Thanks for sharing your success it helps to networking, propel me forward in my own journey #128578; Can I just say what a comfort to find a person that truly knows what they#8217;re talking about over the internet.

You definitely realize how to ncea level, bring a problem to light and make it important. Social Thesis! A lot more people must look at this and understand this side of the story. Politics In Indian Uni! It#8217;s surprising you#8217;re not more popular given that you definitely possess the gift. Shelly, I enjoyed reading your thoughts and too agree that it is never too early to thesis, start teaching our students how to plant hormone research paper, be productive digital citizens. In the age of IM and text messaging I was afraid writing in complete sentences with thought was going to increasingly become a lost art. Children at an early age are thirst for knowledge and just as they are able to more readily learn another language, digital literacy should be considered one of social networking importance. The skills that you develop in plant hormone paper, writing essays should be evident in your blog posts. In fact, these skills should be evident in all of your writing exercises.

Beautifully structured paragraphs and concise sentences are always a joy to social networking thesis papers, read. Essays In America! My brother suggested I may like this blog. He was entirely right. This publish actually made my day. Social Networking Thesis! You can not imagine simply how so much time I had spent for sheridan thesis machine this information! Thanks for the post.

It clarifies my thoughts on social thesis papers the matter, as I sooo agree with your points. (Grammar police on the #8216;so#8217;). previous comments are great I just say that you defined fabulously. Baylor Admissions! This is fact writing can be very helpful just like essay writing which is something more factor by writing an essay is variation use of punctuation. The fact about social networking, essay writing is that it really give your english a better role model for plant hormone paper student and provide non copy content. Blogging has greater potential for networking thesis papers being a life-long skill.

Shelley! Thank you for writing this. We#8217;ve started a new project-based academy at The American School of Lima and on injustice students are constantly blogging. Best of all, they#8217;re loving it and enjoying writing again. Here#8217;s one of many great examples: http://gisellasilva.weebly.com/1/post/2014/03/your-college-search-should-start-with-a-long-look-in-the-mirror.html. Through their blogs, the Innovation Academy students get to reflect on their learning, find their voice as writers, experiment with organization, play with words, and begin to think more clearly and critically. Social Thesis! You#8217;ve put into words what I#8217;ve been discovering through this whole year. THANK YOU!

If you know about Best Essay Writing Services. Politics! I am now a huge fan of social blogging and admissions essay see the real value of sharing ideas and resources as a professional and hope to develop my writing skills through new and interesting blogs I create myself. Networking Thesis Papers! To teach students to blog effectively I think we need to learn how to create interesting blogs ourselves. http://www.dissertationwizards.co.uk. Blogging Is the New Persuasive Essay Things I grab, motley collection - [. ] on plpnetwork.com Share this:TwitterFacebookTumblrPinterestLinkedInDiggEmailLike this:LikeBe the first to like [. ] You Should Read#8230; (June 24, 2012) - [. ] Blogging is the New Persuasive Essay I have said this before, but Shelley Wright is my favourite blogger. Teacher Makes Persuasive Case for Blogging as the New Persuasive Essay Think Now Education - [. ] an English teacher from Saskatchewan, makes that case in a PLPNetwork blog post that the in america, traditional persuasive essay, which Blogging Is the New Persuasive Essay | John Weatherford - [. ] Blogging Is the New Persuasive Essay. [. ] Unlearning Academic Writing | My Wired Life - [. ] this recent blog post, #8220;Blogging is the New Persuasive Essay,#8221; Shelly Wright argues that learning how to write for Blogging is the New Persuasive Essay | MindShift - [. Social Thesis! ] post originally appeared on Voices from the Learning Revolution [. ] What I learned on Twitter this week How Twitter inspired me to hormone research, start students blogging About Teaching - [. ] Take this great article, shared on Twitter by @gcouros, that made me think this week. [. Papers! ] What I#8217;m Reading (weekly) Wearing 500 Hats - [. ] Blogging Is the New Persuasive Essay [. ] Educ 600 Presentation | Personal Electronic Devices in politics uni, the Secondary Classroom - [. ] Shelley, W. (n.d.). Blogging Is the New Persuasive Essay. Powerful Learning Practice.

Retrieved June 29, 2012, from http://plpnetwork.com/2012/06/22/blogging-persuasive-essay/ [. ] The best way to begin writing is to begin writing. aˆ“ Literacy Change - [. ] on all of the comments their blogs receive. When I came across Shelley Wright#8217;s article on blogging as the Typical Problems with Lower Scoring Essays (Part I) | STAARwrite - [. Social Networking Thesis Papers! ] papers I review. The most fundamental aspects of the paper, like organization and content, is dependent on the thesis. You Should Read#8230;(September 9, 2012) - [. ] what we would think of traditional writing exercises (for another great read on baker machine this, check out social networking thesis papers Shelley Wright#8217;s post MiddleWeb's Latest Middle Grades Education Resources | MiddleWeb - [. ] Blogging is the new persuasive essay, says Eng/LA teacher Shelley Wright in essay, this persuasive blog post at the Voices Smart writing smart learning! Teaching using web 2.0 - [. Papers! ] important for essays in america my students to be able to papers, persuasively argue, but now they learn how to do it via blogging, I used to think#8230; Wright#039;sRoom - [. ] important for my students to be able to persuasively argue, but now they learn how to politics in indian uni, do it via Some of papers My Favourite Posts From 2012 - [. ] Blogging is the New Persuasive Essay I could easily share all of Shelly Wright#8217;s posts here, but this Moving from writing to blogging | S.T.E.A.M. at Dickinson Fine Arts Academy - [. ] it#8217;s been a while. I found some good advice, but what stood out to me was this article, #8220;Blogging Constructing an effective blog post | unteaching - [. ] It can help you to thesis machine, develop your writing skills [. ] Reflection [BCM240] | flukeaus - [#8230;] seem like a constructive way to learn the course material. However, I am a big advocate of the blogging Three Ways My Students Blog and Why It#8217;s AWESOME | Three Teachers Talk - [#8230;] test both require students to be effective persuasive writers.

I like this blogger#8217;s post: Blogging is the networking thesis, New Persuasive Why Academic Teaching Doesn#8217;t Help Kids Excel In Life | MindShift - [#8230;] belief that the plant hormone paper, pinnacle of success in English was the ability to write the essay. But I've radically changed Academics: What#8217;s it good for? | Wright#039;sRoom - [#8230;] belief that the pinnacle of success in English was the social networking, ability to plant hormone paper, write the social thesis, essay. But I've radically changed articles that are persuasive | ARTICLE THAT - [#8230;] Blogging Is the New Persuasive Essay [#8230;] BREAK THE BARRIERS aˆ“ USE SOCIAL MEDIA AS A LEARNING TOOL! PART1aˆ“CLASSROOM BLOGS | Aysin Alp#039;s Blog - [#8230;] is also a good way for the introverts to express themselves. As an English teacher, I can say that blogging Homeschooling Help: Don#039;t Be Afraid to Use New Learning Tools (And Why I Let My Son Start Blogging) - Truly Rich Mom - [#8230;] this article on why academic teaching doesn#8217;t help kids excel at life, and university essay this piece on how blogging is Personal Thoughts on social thesis papers Blogging magnifique2016 - [#8230;] came across a blog titled Blogging is the ncea level 1 english, New Persuasive Essay by social thesis papers Shelley Wright yesterday. At first, the writer Annotation for #8220;Blogging is the New Persuasive Essay#8221; Grizzly Bear - [#8230;] #8220;Blogging is the New Persuasive Essay#8221; from http://plpnetwork.com/2012/06/22/blogging-persuasive-essay/ [#8230;] Blog A Tool for Writing Persuasive Essay | delightu95 - [#8230;] I read Shelley Wright#8217;s Blogging is the New Persuasive Essay.

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Iraq War Persuasive Essay Essays and Research Papers. school February 24, 2014 Result of Iraq War In March 20, 2003, the Iraq War was an social papers, invasion force . led by the United States. In the baylor admissions essay, beginning, the government led by social networking papers, George W. Bush claimed that this military operation was necessary in order to plant hormone paper, attack terrorism and eliminate the networking thesis papers, extensive chemical weapons. Politics Thesis In Indian Uni? However, the networking, Iraq War killed hundreds of thousands of people, and the United States has billions of dollars in debt. The huge social unrest that the thesis in indian, war caused in Iraq , happen despite the social networking papers, lack of plant hormone evidence. 2003 invasion of Iraq , Barack Obama , George W. Thesis? Bush 1147 Words | 5 Pages. ? Mode: Argumentative/ Persuasive Thesis statement: There are three main factors that show why the U.S. should now leave . Iraq . In fact, this war is costly both in terms of economic loss and human lives, and baylor university essay, affects the world opinion about the social networking thesis, U.S.

Purpose: to persuade individuals that the U.S should leave Iraq Audience: Students Research Position paper Outlines . 2003 invasion of Iraq , Baghdad , Gulf War 2688 Words | 7 Pages. attacking Iraq , the US will invite a new wave of terrorist attacks The United States has started the in indian, countdown to networking papers, launch a new . war in thesis Iraq . The deployment of 250,000 troops, fighter jets, aircraft carriers and social networking, heavy weaponry in the Persian Gulf shows we are on the eve of war , which most commentators say will soon happen. The United States decided to level 1 english creative, present their own intelligence report before the Security Council, in order to convince the public opinion in America and social thesis, worldwide that the thesis machine, war is networking, now. 2003 invasion of Iraq , Baghdad , George W. Bush 614 Words | 2 Pages. The Iraq War The Iraq war was an armed conflict in Iraq that consisted of . University Essay? two phases. The first was an invasion of Ba'athist Iraq starting on 20 March 2003 by an invasion force led by the United States.

It was followed by networking, a longer phase of fighting, in ncea level creative which an insurgency emerged to social thesis, oppose coalition forces and the newly formed Iraqi government. The U.S. completed its withdrawal of military personnel in December 2011. However, the Iraqi insurgency continues and caused thousands of plant hormone paper fatalities. 2003 invasion of Iraq , Barack Obama , George W. Bush 1727 Words | 5 Pages. S. Papers? invasion of Iraq . Regardless of sheridan thesis your views on the wisdom of that decision, it's fair to say that the results were not what most Americans . Networking Papers? expected. On Injustice? Now that the thesis papers, war is officially over and most U.S. forces have withdrawn, what lessons should Americans (and others) draw from the experience?

There are many lessons that one might learn, of course, but here are my Top 10 Lessons from the exemplars, Iraq War . Lesson #1: The United States lost. The first and most important lesson of Iraq war is that we didn't. 2003 invasion of Iraq , George W. Bush , Gulf War 1223 Words | 3 Pages. Alexis Sutton English 102- Sec 17 Professor Burke October 15, 2012 A War Without Justified Reason The United States declares . war against Iraq (after an attack allegedly by Al Queda, a terrorist group based in Afghanistan) to destroy their nuclear weapons but what about other countries like North Korea’s nuclear weapons? On September 11, 2001 the United States suffered devastating attacks to the Pentagon, Washington and the World Trade Center resulting in the loss of networking papers many innocent civilians lives. 2003 invasion of uni Iraq , Al-Qaeda , George W. Bush 2574 Words | 7 Pages. ? Iraq War , Unjust or Just On March 19th 2003, President George W Bush opened his address to networking thesis, the nation by saying “My fellow . citizens, at this hour American and level 1 english creative writing exemplars, coalition forces are in the early stages of military operations to disarm Iraq , to free its people and to defend the world from grave danger.” (CNN) Bush’s address was the beginning of thesis a costly and long war that resulted in hundreds of essays thousands of causalities and a hefty increase in national debt. Networking Thesis? As the U.S slowly recovers from the tragedies. 2003 invasion of Iraq , George W. Bush , Iraq 1798 Words | 8 Pages. more for ncea level 1 english creative writing, the failed Iraq war . Congress is papers, gearing up to pour more money to baker thesis, stay the course of the past two tragic years. Tell . your Member of networking Congress that not one more dime should go to waging war in essays on injustice in america Iraq . Instead, the U.S. must end the occupation, bring our troops home, and support Iraqi sovereignty.

Many good-intentioned people in the United States say we can't withdraw our troops now and abandon Iraqis to chaos and disorder. Yet the U.S. presence on networking papers the streets of Iraq is fueling animosity. 2003 invasion of Iraq , George W. Bush , Iraq 1145 Words | 3 Pages. Iraq War (Persian Gulf War and the present day Iraq War .) The Persian Gulf . Wars took place in the country of Iraq , located in the Middle East between Iran and ncea level 1 english creative writing exemplars, Saudi Arabia. It is also bordered by Jordan and Syria to the west, Kuwait to the south, and Turkey to the north. Networking Thesis? Only thirty-six miles of sheridan Iraq’s borders touch the thesis, Persian Gulf. Ourselves Essay? During that period, Saddam Hussein was president of the Republic of Iraq , secretary general of the Ba’ath Party, chairman of the Revolutionary Command Council (RCC). 2003 invasion of Iraq , George W. Bush , Gulf War 1979 Words | 5 Pages. b The War in Iraq By Chris Joseph Year 9 What were the social networking papers, negative effects of the US-led invasion of . Baker Thesis Machine? Iraq on the Iraqi people? The war in Iraq was costly, highly opposed and in the end, quite disastrous. It caused a humanitarian crisis in Iraq ; there were serious political consequences, economic consequences, and the destruction of social networking thesis Iraq’s cultural heritage and so it is difficult for anyone to on injustice, justify whether or not the thesis, war was worth it.

Humanitarian Crisis Figure A Iraqi Refugees. 2003 invasion of plant research Iraq , Baghdad , Gulf War 1518 Words | 5 Pages. The U.S. War on Iraq Sam King 12/9/12 Sam King U.S. Social Networking Thesis Papers? History 2 Professor Christoforo 12/9/12 When the allied troops . returned home after WWII with the enemy vanquished and machine, liberty on papers the rise, the United States of America entered into its most prolific and essay, expansive years in history and suddenly found themselves at the head of the world table. Times of trouble were resolved with us on the frontlines doing whatever was necessary.

Its identity as the land of networking liberty, the essays in america, beacon of hope. 2003 invasion of Iraq , Barack Obama , George W. Bush 1764 Words | 5 Pages. Summary/Strong Response War in Iraq. Summary/ Strong Response In the piece, The U.S. Invasion of Iraq Was Not Justified, Mr. Michael T. Klare argues that there is no possible . way to justify the invasion of Iraq by social thesis papers, the United States government. He objects nearly every conceivable justification for sheridan, the invasion; namely, the argument that the Bush Administration never had evidence of Weapons of Mass Destruction. He objectively blames the Bush Administration for the deaths of American soldiers, only to be followed almost mimicking. 2003 invasion of Iraq , George W. Bush , Gulf War 1079 Words | 3 Pages. “The Decision to go to war with Iraq ” (Pfiffner, 2009) is an analysis of the factors that led G. W. Bush and his . administration to invade Iraq and overthrow Saddam Hussein and his government.

Pfiffner provides a short historic background explaining the social, reasons this decision was made. According to his essay these reasons relate closely to the G. H. W. Bush administration that in the 1990s decided against invading Iraq and overthrowing Hussein. Public officers, who were assigned in critical. 2003 invasion of ncea level 1 english creative exemplars Iraq , Bill Clinton , Democratic Party 1269 Words | 4 Pages. 2; Period 4 6 March 2013 Persuasive Essay Although many countries use nuclear weapons, it is a struggle for them to social, realize . that it is very destructive and our daughters ourselves, harmful to the people and land. One nuclear bomb can kill a many as an entire city, and can cause many long-lasting effects on peoples lives. The use of nuclear weapons is never justified, it is destructive to the country and can kill many innocent people. Many people say that nuclear weapons should be used in war . One example is that there. Atomic bombings of Hiroshima and Nagasaki , Hiroshima , Little Boy 905 Words | 3 Pages. Persuasive Essay Ryan Murphy COMM/215 March 6, 2013 Gary Christiansen Persuasive Essay . Sequester, what is it? How did we get here?

Who is at fault? These are the thing we will discuss. Recently a lot of people have been in an uproar over social networking thesis sequester and the spending cuts that will automatically take place. What most people fail to plant research, understand is that this is not something that happened overnight it has loomed over us for months and our government has failed to take appropriate action to thesis, prevent. Barack Obama , Democratic Party , George W. Bush 980 Words | 3 Pages. The Vietnam War versus the Iraq War With a husband in the Army and our daughters ourselves essay, currently on his third deployment to . Iraq , I am often asked how I think this war is different from social, past wars . Ncea 1 English Exemplars? In order to answer this question properly, I found that I needed to do a little bit of research and acquaint myself with some war history. Social Networking Thesis? As I learned about previous wars that Americans have been involved in, I learned that only two wars have had a great deal of controversy. The Vietnam War and the Iraq War , while almost. 2003 invasion of Iraq , George W. Bush , Gulf War 1110 Words | 3 Pages.

Following the military achievement of the US in uni Afghanistan, the US focused its attention on Iraq in order to topple Saddam Hussein. Social Networking Papers? The . Essays In America? Iraq War was a conflict that took place with the social networking thesis papers, invasion of Iraq by the US on 20 March 2003. The American government offered two significant reasons for waging war against Iraq in 2003 (Klare, The Coming War with Iraq , page 3). Thesis In Indian? First of all, the US claimed that Iraq have weapons of mass destruction that could be captured and used by terrorists organizations and. 2003 invasion of Iraq , Baghdad , George W. Bush 2565 Words | 7 Pages.

War on iraq was not justified The 2003 Iraq War lasted less than three weeks. It began in the . early morning hours of March 20, when American missiles struck Baghdad. By April 9, U.S. forces had advanced into papers Baghdad. By April 15 Iraqi leader Saddam Hussein had vanished, and U.S. and allied officials pronounced the end of major combat operations. Although the war itself was short, arguments over whether it was justified had been made for months and years prior to the attack, and still continue. 2003 invasion of Iraq , George W. Bush , Gulf War 1560 Words | 4 Pages. The Iraq War was Unjustified University of Phoenix MU11COM09 September 9, 2011 Comm/215 Essentials of College writing The . Iraq War was Unjustified There are many reasons why the ncea level creative writing exemplars, war Iraq was unjustified. Until today, Iraq has not been found to have weapons of mass destruction. There are beliefs that former President George W. Bush simply waged war on Iraq because of their oil.

Iraq as a country and the former President Saddam Hussein had no link to al-Qaeda terrorist group. The United. 2003 invasion of social networking thesis papers Iraq , George W. Bush , Gulf War 861 Words | 3 Pages. Argumentative Essay Nobody likes war ; it is so costly in our daughters ourselves essay so many ways. Lives are lost, property is destroyed, people are . injured and thesis, some are disabled mentally and physically.

Because of ncea 1 english writing exemplars this many people think war must be avoided at all costs. Networking Papers? All these facts regarding the high cost of war on a country are true. On the other hand there are situations in creative exemplars which a nation has an obligation to go to war . Thesis? Their were many times in the United States history when the in indian, decision to enter a war was in. 2003 invasion of papers Iraq , George W. Bush , Iraq War 920 Words | 3 Pages. ? Post- War Conditions in Iraq Roger G. Schoen PSYCH 620 March 2 2015 Jennifer Friedrich Post- War Conditions in . Iraq “I think we ought to bring some of the Iraqis (Republican Guard) here and let them take a good look” General Norman Schwarzkopf On August 2 1990 Saddam Hussein and university, his forces invaded Kuwait and by August 7th the social networking, 24th Infantry Division (ID) which I was a part of, had orders to thesis in indian uni, deploy to Saudi Araba for a build up to war , Desert Shield -Desert Storm. On 24 February 1990 the. 2003 invasion of Iraq , Baghdad , Gulf War 1532 Words | 7 Pages. Waging War For What? I’m sure most, if not all of social you, are all familiar with the recently ended Iraq War . Essays On Injustice In America? Well how . Social Networking Thesis? would you like to hear that this 8 year long war was not even justified? According to the just war theory the well-known Iraq War is considered not a just war . Why you may ask? Well the just war theory has many different criteria and regulations that have to be met in essays in america order to consider a war just.

Focusing in on a few of those criteria has determined that it is indeed not a just war . Some. 2003 invasion of Iraq , Gulf War , Iraq 1872 Words | 5 Pages. Countries involved on the Iraq war. ?CHANGING CHARACTER OF WAR WHAT COUNTRIES WERE INVOLVED IN THE WAR ? Apart from US, there were other countries involved on the . Iraq’s war . USA’s main supporter was Britain. Even though British citizens were sure that UK shouldn’t join the war , Prime Minister Anthony Blair had a relationship with US President, George Bush, and said that UK was going to social papers, ‘pay’ this special relationship supporting and essay, helping US in thesis the war ; he promise his full support to uni, Bush and sent up to 30.000 troops.

Presidents. 2003 invasion of Iraq , Iraq War , Kofi Annan 828 Words | 3 Pages. United States and social networking, Britain and our daughters ourselves, eventually led to social, the War of 1812. In a similar context, the Iraq War was also a . On Injustice? direct response to the evidence supporting the fact that Iraq was connected to terrorist activities and the assumption that Iraq was hiding weapons of mass destruction. The US response to Russia in the Cold War is similar to the US response today and set the social papers, precedent for the Iraq War . Politics Thesis? Conclusively, both the War of 1812 and networking, the current war in Iraq can be justified considering that the country. 2003 invasion of Iraq , Cold War , George W. Baylor Essay? Bush 1673 Words | 5 Pages. Canada's Involvement with the War in Iraq.

CANADA'S INVOLVEMENT IN THE WAR WITH IRAQ CANADA'S INVOLVEMENT IN THE WAR WITH IRAQ Since the . Social Thesis? attacks on the World Trade Center in 2001, U.S allies have been faced with many new decisions. Canada is one of the closest allies of the politics uni, United States and has long shared the same goals, making the controversy surrounding the U.S. war with Iraq one of importance for the Canadian parliament and its citizens. Questions of justification and UN implications have left the social papers, country with mixed feelings. 2003 invasion of Iraq , Baghdad , Canada 2247 Words | 7 Pages. Persuasive Essay The idea of a doll who is hormone, supposed to teach my child and she what a cute young girl looks like, would you . think it would be dress to a parents idea of cute? The Bratz Dolls are unbelievably dressed and constructed. There has recently been much controversy over these dolls in my home town. Networking? It was a young Childs birthday party; she received a Bratz Doll as a present for her party. The following is the story that was written on what happened after the mother opened the gift and. Barbie , Bratz , Bratz Babyz 860 Words | 3 Pages.

The Iran- Iraq War (1980-1988) The Iran- Iraq War was one of the politics uni, numerous armed conflicts between . these historic countries. Conflict dates back centuries to social networking papers, the days of the Ottoman Turkish Empire and the Persian Empire under the Safavids. Iraq was the easternmost province of the Ottomans and Iran, the center of the Persians. Disputes then stemmed from many of the sheridan baker thesis machine, same things that conflict arises from social networking papers, today. This includes border disputes, religious animosity, cultural differences, and interference. 2003 invasion of thesis Iraq , Baghdad , Iran 1929 Words | 5 Pages. 10/29/07 An Inevitable War : Iraq [pic] “We may have had enough troops to win the war -but not nearly enough to win . the peace.” (Philip Carter, 2003, p. 82) There is much debate going on in the U.S. about the war in Iraq . Papers? Some people argue that the U.S is fighting a war that it should never have started; others argue U.S. intervention on thesis Iraq has created a war with no end and we should come home immediately. However, I strongly believe that the social thesis papers, war in Iraq was an inevitable, justified war and that, from a.

2003 invasion of Iraq , Baghdad , George W. Bush 2809 Words | 7 Pages. Ethical Implications of the War in Iraq. Ethical Implications of the War in Iraq : A Consequentialist Perspective The purpose of this paper is to argue that there was . no humanitarian cause for the invasion of Iraq . I agree with Ken Roth’s analysis that the war in Iraq was not for humanitarian purposes and I would subsidize my reasoning with Peter Singer’s ideas of plant hormone utilitarianism and consequentialism. I will first look at networking thesis papers Ken Roth’s analysis; secondly I will analyze Peter Singer’s argument and apply it to Ken Roth’s analysis. Finally. 2003 invasion of sheridan baker thesis Iraq , Baghdad , George W. Bush 1242 Words | 4 Pages. Persuasive Essay Erica Crawley COMM215 August 10, 2014 University of Phoenix Running head: PERSUASIVE . ESSAY 1 PERSUASIVE ESSAY 2 Persuasive Essay Many people can benefit from joining the social, Military service for a lot of different reasons. Some joined for the pay, to university, serve their country and some do it for papers, the experience.

There are many reason people join the United States Army. Some other reasons to join the Army could be job security, education benefits, health insurance benefits, life. Ernest McFarland , G.I. Bill , Health insurance 779 Words | 3 Pages. thousands of lives later we are still fighting a meaningless war . The U.S. invaded Iraq to get rid of their weapons of mass . destruction, to help fight the war on terrorism, and to get rid of Saddam to set up a democracy. We have clearly failed in our attempt to achieve any of ourselves these so there is no reason that we should still be in Iraq . Social Thesis? The War in Iraq is wrong and we should pull out our troops in immediately. The main reason that we went into Iraq was to research, take out Saddam Hussein because the Bush Administration.

2003 invasion of Iraq , George W. Thesis Papers? Bush , Gulf War 1122 Words | 3 Pages. ? Sydia Smith December 17, 2013 ENGL 101 Persuasive Essay Assignment: For generations people . of color have been put into a system caste of plant paper injustice. From slavery, to the Jim Crow era, and social thesis papers, now in today’s society. In America? Today in the United States the networking, incarceration rate has nearly tripled over the years. Our Daughters Essay? With the significant increase in the incarceration rates, it leads you to wonder what the social networking, cause may be. The government has found a way to indirectly create another system. African American , Drug addiction , Incarceration 1013 Words | 3 Pages. PERSUASIVE ESSAY COMM/215 ESSENTIALS OF COLLEGE WRITING JANUARY 20TH, 2013 The use of guns is everywhere nationwide. . Many families and individuals own a gun for their own personal protection. Some families only feel comfortable owning a gun in their home to protect their families, than Sandy Hook happened and the world started turning.

All of the sudden guns became dangerous but what people don’t understand is that before that tragedy happened many families and individuals still had ownership. Cannon , Firearm , Gun 812 Words | 3 Pages. The US- Iraq War , a military action led by the United States against the regime of baylor university Saddam Hussein, the authoritarian leader of . Iraq . US president George W. Bush, who announced the beginning of the war in papers March 2003, explained that the goals were to disarm Iraq and to free its people. For months, President Bush had threatened war , arguing that Saddam Hussein's regime posed a grave threat to US security and peace in politics thesis in indian uni the region because of its alleged pursuit of weapons of mass destruction. The conflict. 2003 invasion of networking papers Iraq , Abu Ghraib torture and creative writing exemplars, prisoner abuse , George H. W. Bush 1384 Words | 4 Pages. The Effects of the Iraq War Shelly Johnson Research Writing/COM 220 August 20, 2010 Instructor Sharon Cronk-Raby The . Social Thesis? Effects of the Iraq War The media and essay, the military are focused on networking thesis the positive effects of the Iraq War and how the soldiers have a job to defend the country, which is politics thesis uni, true. There are also many negative effects the war has had on the soldiers and their families.

It is safe to assume that all soldiers are affected by their experiences in networking papers war . These soldiers are coming home to. 2003 invasion of Iraq , Army , Iraq War 2274 Words | 6 Pages. Writing assignment seriesPersuasive or argumentative essaysIn persuasive or argumentative writing, we try to convince othersto agree with our . facts, share our values,accept our argument and conclusions,and adopt our way of hormone research paper thinking.Elements toward building a good persuasive essay include establishing factsto support an argument clarifying relevant valuesfor your audience (perspective) prioritizing, editing, and/or sequencingthe facts and values in importance to build the argument . Argument , Conclusion , Logic 691 Words | 3 Pages. The Iraq war , also known as the networking, second Gulf War , is a five-year, ongoing military campaign which started on March . 20, 2003 with the invasion of Iraq by U.S. troops. One of the ncea writing exemplars, most controversial events in the history of the western world, the war has caused an unimaginable number of deaths, and networking, spending of ridiculous amounts of money. The reason for invasion war Iraq’s alleged possession of weapons of thesis in indian uni mass destruction, which eventually was disproved by weapons inspectors. Many people question.

2003 invasion of Iraq , George W. Bush , Gulf War 1198 Words | 3 Pages. The Iran- Iraq war , also known as the First Gulf War , was fought between the countries of Iraq and . Iran from September 1980 to August 1988. The Iraqi invasion of Iran triggered the start of the war , and thesis papers, thus began what it would be considered as the longest conventional war of the twentieth century. Iraq , after having a long history of territorial disputes between Iran and admissions essay, fearful of losing its rich oil fields, decided to become the social, supreme power in the Persian Gulf by launching a simultaneous air. 2003 invasion of level writing Iraq , Baghdad , Gulf War 1142 Words | 3 Pages.

? Persuasive Essay Many movies, television shows, music songs, and video games are filled with violence: murder scenes, nonstop . profanity, rape and networking, torture scenarios. By placing scenes like these in baker thesis the movies for social thesis, the children and teenagers to see, the media is causing them to become more violent than it already is. What has our society come to these days? Everywhere we look, violence is present; in level creative the streets, back alleys, schools, and even at home. Social? Even if one might be a pacifist, violence will. Columbine High School massacre , Media violence research , Seung-Hui Cho 888 Words | 2 Pages. ? War in Afghanistan and Iraq The United States of American is the greatest country in the world and because of that, the . attraction for terrorism is always a concern.

On September 11, 2001, the concern became reality when the world trade centers were attacked by terrorists and essays, as a result, thousands of Americans lost their lives. America reacted by launching anti-Taliban operations, the first starting in Iraq then in Afghanistan. The first mission was Operation Iraqi Freedom. The purpose of this. 2003 invasion of Iraq , Al-Qaeda , George W. Bush 2020 Words | 5 Pages. Iran- Iraq War The Iran- Iraq war was a brutal war that eradicated thousands of . Thesis Papers? lives. Some say that “ It was a big mistake” or “wasn’t meant to be.” Both sides argued their own perspective, in a matter that they were more accurate than the essays, other, or that even it wasn’t their fault.

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This is social networking, so over-used. If you were not passionate about an aspect of the role, it is assumed that you would not be applying for the position. So, set yourself apart from the average candidate by trying something different, like noting how fulfilling the passion makes you feel. It is important to note that you enjoy a collaborative atmosphere, but the phrase “team-player” is contrived. Alternatively, refer to ncea level 1 english creative, a success story of when you worked alongside someone else to networking papers, bring great benefits to the workplace. The advice above can help to shape a CV, but doing any of the following can seriously damage your chances of acquiring the customer service job that you crave. CVs should never be written in third person. Use first person and choose the politics thesis in indian uni present or past tense to showcase the most important and relevant information to your employment goals. So, for example, do not say “James Bell is…” , but instead state “I am…” . Things to social papers, include: your address, postcode, mobile number and email address! So many people are not including this information, making it very difficult for agencies and hormone, organisations to know where candidates are looking for work and also to register the CVs on their systems. It also makes it impossible to find candidates again when searching in specific locations.

This is thesis, just a waste of space, especially as you should already be struggling to cut your CV down into two pages. Also, don’t save your CV as an Infographic. These may look good, but they can’t be used by agencies and often won’t upload to level writing, company career sites – send your CV as a PDF or Word document and keep the formatting simple! Expanding Margins and Cutting White Space. No one wants to read a CV that is formatted with a tiny font and no white space! White space allows the eye to rest between reading and networking papers, absorbing the content, and it acts as a cue to important information the employer should read with care. At the same time, a CV with too much white space will look like you have no relevant experience or skills to 1 english creative writing, offer the employer.

Find a happy medium – keep the CV readable and clean, while filling the space. Including Spelling, Grammar and Punctuation Mistakes. In this day and thesis papers, age there should be NO excuses, but it still happens, and essays, more often than you would expect. These kinds of mistakes can get even the most qualified candidate’s CV thrown into social thesis the “no” pile. Remember, the CV is an excellent way to demonstrate to level 1 english, potential employers or recruiters what type of employee you are, your attitude to social papers, work and, most importantly, your attention to detail! After you have reviewed your CV carefully, have a friend – or two – review it again for you! Heavily Detailing Secondary Experiences. It is very easy to keep adding a new job to your existing CV, but does your previous role still hold any relevance? Or, looking back, should your previous role actually be enhanced to support more of our daughters essay, your present role?

As your career progresses, your older jobs may not be as relevant as they once were. Social Papers? Your CV is your opportunity to showcase your career and you need to highlight what is most important, taking space from sheridan baker thesis machine, less important detail that you may now be able to remove. Listing Your Duties from networking thesis, a Previous Job. Everyone needs to see and understand what you do, but what is it that sets you apart from the crowd? In addition to listing some, if not all, of your duties and responsibilities, try and include some achievements, tangibles, or context around the role. This could involve something like the following:

You may write: I am responsible for 100 + FTE. You could write: I am responsible for the leadership, coaching and development of 100 FTE. In the past year we have seen an uplift of 5% on service level performance against politics in indian uni, the previous 5 years. Do you agree with our lists? Which other words would you have included or perhaps excluded? Please leave your thoughts in the comments section below.

Visit our jobs page to find your next opportunity. Published On: 23rd May 2017 - Last modified: 22nd Sep 2017. These phrases are positive and dynamic . I’m re-writing my CV at the moment and find this really useful. I’m currently re-writing my CV. Trying to find words to social thesis papers, describe my transferable skills, i’ve used ”HIGHLY motivated and EXTREMELY punctual” but struggling to ourselves, find more. This is a wonderful an social thesis, important material to increase the knowledge in these kind of topics. I apprecite your special help. Thank you for posting this wonderful tool.

I have included many of these words in my resumes and politics in indian, applications, and i think that they put me over the other applicants with the same qualifications. Amazing I’m using this for social networking my interview. Aamazing. what a load of rubbish. why cant you just be yourself why do we all have to conform to the same surely its all about what you have to say soon we be like a communist state……. Brilliant help. Thank you. I knew that my daughter was good at and what her personal traits are but I just couldn’t think of the right words.

Well done! i am always trustworthy. This is very good. You should also do negative words so that we can understand what not to use in our CV. Used correctly and appropriately, the above words can work wonders. However, there is a risk that they are over-used or (worse) used as ‘filler’, where the CV ends up being a mish-mash of buzz-words. Use these key ‘postivifiers’ succinctly rather than sporadically thrown in, and you will see far more companies return to level 1 english, you offering an interview. You are a life saver! awarded is a good word to use. Yeahhhh, conform to social thesis papers, not being conformist. Cv are hard as employers usually only look at the cv for about 4/6 seconds.

Getting a job now is more about politics, who you know, rather than what you know.. Social Papers? Etc.. If your face fits and are incapable of the job then you are fine. Keeping at in america it people #128578; Something always comes along. This is amazing, I used this via email and it worked wonders. Thank you. DO NOT use any of these words. DO NOT say ‘I am creative/energetic/hardworking/dependable’. What have you done that shows you are creative, energetic hardworking/dependable?, use your achievements to highlight your skills and let the social networking thesis papers employer judge for in america themselves! These so called ‘buzz-words’ are found on every cv, use creative ways of writing to give the same impression…

Having read all the praise and social papers, criticism I can say that you’re all right and also wrong. In fact its both… Yes, use these words to ensure you have said what needs to be said however, that alone will not win you an interview. Ncea Level 1 English Creative Writing Exemplars? To say ‘don’t use these words’ is also pretty stupid as you’ll end up with the CV that doesn’t say ‘honest’ etc so, at least bring yourself in line with everyone else at that stage! To win an interview you need to write basic information SUPPORTED with substantial evidence of competence. Social Networking Thesis? For example, a sales person stating only their title, dates and role responsibilities is nearly a total waste of time. Our Daughters Ourselves Essay? Instead, support this with achievements: Target of X, won Y. Thesis? Won X client, grew Y account by hormone paper, ?20k, increased GP by 47%, etc.

Think about the key skills required to do the job well and focus on providing evidence that you can do them. e.g. Networking Thesis Papers? Communication, Negotiation, Closing, etc – then add an example/result of having done it. Simple. If you’re in a job where success is harder to quantify than a sales role think about how your manager measures your performance. Machine? If he/she targets you on cost savings, lead times, quality, complaints, etc then that dictates your achievements. Social Networking Thesis Papers? Remember that if you’re going for a job in ourselves essay the same sector with similar managers, speak their language to impress them. Also, think about the changes you have introduced that have had a positive impact on networking thesis your employer’s business. Each one is an achievement, even if its not work related! (e.g. Level 1 English Writing? started social events, charity runs, etc) In short, its WHAT YOU DID, not just a regurgitated job description and networking, dates. Great article, thanks!

This is great. Thanks. Get answers from the Call Centre Helper community on your most difficult challenges.

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Essay: Oral administration of drugs. Today various routs available for the administration of drugs but the oral route is the simplest and most preferable route for the administration of dosage forms. Different dosage forms are available for social networking the administration orally. 3. Emulsion suspensions. 4. Solutions etc. But the problems is there in the recently invented drugs having problem with there bioavability approx. 50% of newly marketed drugs can not be given orally due to poor solubility.

The poor solubility of drugs can reduce the bioavability of dosage forms. Recent approaches have included the administration of drug components with lipid vehicles such as oils, liposomes and admissions self-emulsifying formulations [1, 2]. Social Papers! This system was not use commonly but know the days importance of lipid based drug delivery system is university admissions essay very height due to social papers poor water solubility of ncea writing exemplars drugs. For the improving bioavability we formulate a new drug delivery system called self emulsifying drug delivery system By example, the bioavailability of Tipranavir (TPV), a nonpeptidic protease inhibitor anti-HIV drug, was doubled when dosed to rats in a SEDDS formulation versus delivered as solid powder in a hard filled capsule [3]. developed a self-emulsifying drug delivery system for Coenzyme Q10 using polyglycolyzed glycerides as emulsifiers with a resultant 150% increase in bioavailability.4 Numerous other examples exist in the literature demonstrating enhanced bioavalibility with self emulsifying drug delivery systems 5-6 but most focus on networking thesis a single formulation or small.[2] set of formulations with little explanation of how this formulation was developed. Level Creative Writing! Current SEDDS formulation development, consequently, in general occurs through resource-intensive trial and error. Some mechanistic studies have been conducted exploring a range of SEDDS formulations and a specific aspect of their function, most commonly ability to emulsify [7, 8]. . Improved quantitative understanding of how properties of a specific self emulsifying formulation interact with the networking thesis biological environment to enable oral absorption could help optimize SEDDS formulations for enhancing bioavailability. Although a significant amount of literature exists from research other fields concerning the function of emulsions [9-10], pharmaceutical formulations have not been broadly studied with respect to social networking papers fundamental aspects of emulsion function, with few studies statistically developing predictive models that relate emulsion properties with formulation parameters [11]. In particular, analysis and optimization of emulsion function across a broad range of formulation parameters via experimental design has not been widely explored. One poorly understood aspect about SEDDS is the on injustice in america influence of different formulation components on the overall performance of social thesis papers these drug delivery systems in vivo.

Different types of oils with different characteristics and different surfactants combined at different ratios may influence the performance in vivo drastically. Exemplars! There is no guidance currently available for formulating a drug with specific properties with self. emulsifying drug delivery formulations.12 It is social networking thesis papers therefore necessary to investigate the influence of formulation components with a quantitative and statistically designed and analyzed manner. 3 Another knowledge in which there is a lack of sheridan thesis machine understanding is the mechanism of how self emulsifying drug delivery systems work to enhance the overall bioavailability of a hydrophobic drug orally. Suggested mechanisms responsible of functioning of SEDDS in the GI tract environment includes the increased drug solubilization in the aqueous lumen phase due to alterations in the composition and character of colloidal environment in the GI tract fluid and increased drug absorption due to enhanced permeability permeability (e.g. widening of networking thesis papers tight junctions, changes to our daughters ourselves cellular processing) and lymphatic transport [13-14-15]. Important mechanisms that would influence drug solubilization in social papers, the lumen is the rate and extent of digestion of lipidic formulation components. Another one is the rate at which the drug is released from oil droplets especially during the process of ‘degradation’ of the emulsified drug carriers by ourselves essay the digestive enzymes in vivo. Social Networking Papers! It is ourselves essay essential to thesis papers investigate the rate of digestion of self emulsifying formulation lipids, rate of drug release, as well as the rate and extent of drug transport across intestinal monolayer incorporated with SEDDS in order to understand and predict formulation functioning in hormone research, GI tract. Knowledge gained from these mechanistic understandings can be used as quantitative expressions which then can be incorporated into a pharmacokinetic model that will predict oral bioavailability of a drug administered with self emulsifying drug delivery systems. To define and understand challenges involved with oral delivery of hydrophobic drug compounds it is social papers necessary to present a overview of current technologies.

16. Oral intake has been the most sought-after route of drug delivery by the patients as well as the manufacturers for the treatment of most pathological states. Despite tremendous strides made in novel non-oral drug delivery systems (DDS) till date, majority of the drug formulations available in the commercial world today are the oral ones.17 Nevertheless, oral delivery of over one-half of the drug compounds through gastrointestinal (GI) tract gets diminished owing to plant hormone research paper their high lipophilicity and consequently poor aqueous solubility. Social Networking Thesis Papers! Oral bioavailability of such drugs, being primarily a function of essay their solubility and dissolution,[18-19] tends to exhibit inadequate magnitude with high intra- and inter-subject variability. Besides, oral bioavailability also depends upon a multitude of other drug factors such as stability in GI fluidsintestinal permeability, resistance to metabolism by cytochrome P450 family of enzymes present in gut enterocytes and liver hepatocytes, and interaction with efflux transporter systems like P-glycoprotein (P-gp).[20,21] explicitly illustrates the thesis mechanisms of the physiological pathways through which the bioavailability of a drug from the level writing conventional formulations tends to get impeded. Several formulation approaches have been employed to improve the oral bioavailability of diverse drugs.

Amongst these, oral lipid-based DDS have proved their immense potential in improving the poor and inconsistent drug absorption of many poorly water-soluble drugs, especially following their administration after meals.22 These include various types of lipid suspensions, solutions and emulsions.23 With applications in specific domains, the lipidic formulations, thus, have carved a singnificant niche in oral drug delivery. Networking! Self-emulsifying drug delivery systems (SEDDS) are relatively newer lipid-based technological innovations with immense promise in oral bioavailability enhancement of drugs. These formulations have shown to baylor essay reduce the slow and incomplete dissolution of a drug, facilitate the formation of its solubilized phase, increase the extent of its transportation via intestinal lymphatic system, and papers bypass the P-gp efflux, thereby augmenting drug absorption from the GI tract.24. Self emulsion having grate capacity yo increase the bioavability of poorly water soluble drugs. It’s a isotropic mixture of oil ,surfactant, co-surfactant.in this system oil globules bind with drugs and increase the solubility of drugs. SEDDS is also known as microemulsion system. Ourselves! It will increase bioavability of drugs 50-100% .25-26. 1. Solid self emulsifying drug delivery system (SSEDDS) 2. Liquid self emulsifying drug delivery system (LSEDDS)

Recently day by day a new drug molequle was found but the social networking thesis only problems is that the bioavability of the drugs. Because oral route is the most preferable route for the administration of ourselves drugs but poorly water soluble drugs having problems to networking formulates solid dosage form because it will reduce the bioavability of drugs.26. In the solid dosage forms numbers of excipients are use for the increasing drug solubility. They can be help in enhancing the solubility of drugs. In the SEDDS we number of excipients are use. 3. Co- surfactants. 4. Solidifying agent. They all the excipients help in our daughters essay, the inhancing the bioavability of drugs.26. SEDDS is the networking papers isotropic mixture of sheridan baker oil, surfactant and co-surfactant. Thy having the capacity to rapidely dissolve in stomach and instinal fluid and cover large surface area. due to this nature of networking SEDDS it will also use in the sustain relese drug delivery system for the instant delivery of drugs. This system can be use to increase the solubility of drugs by the help of excipient’s in the oral dosage forms we can use PH modifier, water soluble organic solvents, surfactant, co-surfactants.

And oils are use long chain triglicryde and medium chain tryglyceried we also use PEG 400, propylene glycol, glycerin, non-ionic surfactants as water soluble organic solvents.36,37. 1.1 Composition of SEDDSs:- ‘ The nature of the oil’surfactant pair. ‘ The surfactant concentration. ‘ The temperature at plant research paper, which self-emulsification occurs. 1.1.1 Oils:- Oils can solubilize the lipophilic drug in a specific amount. It is the most important excipient because it can facilitate self-emulsification and increase the fraction of lipophilic drug transported via the intestinal lymphatic system, thereby increasing absorption from the GI tract . Social Networking! Long-chain triglyceride and level creative writing exemplars medium-chain triglyceride oils with different degrees of saturation have been used in the design of SEDDSs. Modified or hydrolyzed vegetable oils have contributed widely to the success of SEDDSs owing to their formulation and physiological advantages. Novel semisynthetic medium-chain triglyceride oils have surfactant properties and papers are widely replacing the regular medium- chain triglyceride. 1.1.2 Surfactant:- Nonionic surfactants with high hydrophilic’lipophilic balance (HLB) values are used in baylor essay, formulation of SEDDSs (e.g., Tween, Labrasol, Labrafac CM 10, Cremophore, etc.). The usual surfactant strength ranges between 30’60% w/w of the formulation in order to social networking form a stable SEDDS.

Surfactants have a high HLB and level creative exemplars hydrophilicity, which assists the networking thesis papers immediate formation of o/w droplets and/or rapid spreading of the formulation in in america, the aqueous media. Thesis! Surfactants are amphiphilic in ncea level 1 english writing exemplars, nature and they can dissolve or solubilize relatively high amounts of hydrophobic drug compounds. This can prevent precipitation of the drug within the GI lumen and for prolonged existence of drug molecules. 1.1.3 Cosolvents:- Cosolvents like diehylene glycol monoethyle ether (transcutol), propylene glycol, polyethylene glycol, polyoxyethylene, propylene carbonate, tetrahydrofurfuryl alcohol polyethylene glycol ether (Glycofurol), etc., may help to dissolve large amounts of hydrophilic surfactants or the hydrophobic drug in the lipid base. These solvents sometimes play the role of the cosurfactant in the microemulsion systems.27.

1.2 Microemulsions or Self-Emulsifying Drug Delivery Systems (SEDDS) Emulsions in social papers, general are thermodynamically unstable systems. Sheridan! The droplets of the dispersed phase are large. Microemulsions on the other hand are emulsion systems that have a droplet size of a few to hundreds of social nanometers and are typical complex fluids that consist of our daughters three essential components: two immiscible fluids and a surfactant. Typically these are water-in-oil or oil-in-water microemulsions where the rheological properties of papers these two liquids and microstructure of the surfactant strongly affect the level 1 english creative resulting microemulsion . Microemulsions and micellar solutions are distinguished from emulsions by the fact that the networking thesis average drop size does not grow with time, which is a manifestation of thermodynamic unstability. Micellar solutions and microemulsions on the other hand are assumed to be thermodynamically stable. Reasons why there is tremendous attention on uni SEDDS include industrial trend towards the discovery and development on hydrophobic drugs and the resolution of technology transfer, stability and regulatory issues by SEDDS and the fact that they have proven pharmaceutical benefit with commercially available compounds of up to 5 fold increase in bioavailability (cyclosporine, lipid soluble vitamins, HIV protease inhibitors etc.) Self-emulsifying drug delivery systems by definition are mixtures of an oil, one or more surfactants and optionally a co-solvent or co-surfactant which when introduced into an aqueous media, under gentle agitation, forms fine oil-in-water emulsions. Networking Thesis! These systems when incorporated with a drug compound, drug is politics thesis distributed in the aqueous solution entrapped inside oil droplets. SEDDS enable distribution of hydrophobic drug component in the aqueous media and creates a drug solubilization in the gastrointestinal environment. Distribution of drug inside oil droplets prevents drug from being an undisolved substance, precipitating and networking being excreted from sheridan thesis body.

However their mechanisms of action in social networking thesis, the body are not limited to solubilization enhancement and also include other processes such as intestinal permeability and lymphatic transport enhancement. SEDDS by in indian nature are thermodynamically stable emulsions compared to unstable regular emulsions. Their stability is thought to be dependent on their relatively small dispersed oil droplet size and narrow range of droplet distribution. SEDDS are typically composed of emulsion droplets having a diameter of 50 nanometers to 500 nm whereas systems having droplet size less than 50 nm are called self nano emulsifying drug delivery systems (SNEDDS). For a given drug only very specific formulations will give efficient emulsification and a self-emulsifying system that will work to enhance bioavailability. Efficiency of SEDDS therefore, as explained in detail by Gursoy et al., is governed by surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size and charge of the droplets. However, the mechanism that governs self-emulsification has not yet fully understood. It is suggested that water penetrates through the gel and social LC phases that occur at sheridan machine, the surface of the droplets. This is followed by the solubilization of the water in oil phase until the solubilization limit is reached. Social Networking! After the limit is reached, formation of dispersion of LC phase is formed and this depends on the surfactant concentration. Wit this formation, SEDDS become resistant to coalescence.

Emulsion stability is governed by our daughters essay a variety of factors such as physical nature of the interfacial film, presence of electrostatic or steric barriers on the droplet, viscosity of the continuous phase, droplet size distribution, oil to water ratio, temperature and networking papers the amount of surfactant that is absorbed on the surface of the oil droplet. The more surfactant is absorbed on the surface, the more decreased the interfacial tension between oil and water which consequently yields delayed coalescence of droplets by electrostatic and steric repulsio. Although with the addition of hormone high amounts of drug, which is common case for networking papers potential oral dosage forms, it is harder to level have stabilized emulsions. Networking Thesis Papers! In this case, the need of using more surfactant arises that have negative aspects such as increased toxic effect of the formulation. 1.3 ADVANTAGES OF SEDDS :- ‘ More consistent drug absorption, ‘ Control of delivery profile. ‘ Reduced variability including food effects.

‘ Enhanced oral bioavailability enabling reduction in dose. ‘ High drug loading efficiency. ‘ For both liquid and solid dosage forms. ‘ These dosage forms reduce the gastric irritation produced by drugs.25-26. 1.4 APLLICATION OF SEDDS : Main application of this SEDDS to essay increase the bioavability by increasing the solubility of drugs. In this system we use oils for the increasing the solubility of drugs . the oils can form a layer of globules on social papers the drug so it will easily dissolve in the water.27.

1.5 Solubility and Process of Solubilization. In bioavailability of baker thesis drug, solubility plays a key role because it is vital determinant of drug release and absorption. Any drug showed pharmacological response when it achieves desired concentration in social, systemic circulation and it is depending upon solubility. Solubility is the maximum amount of solute dissolved in a certain amount of solvent at a specified temperature. (Shinde A. J., 2007) 1.5.1 Process of plant hormone paper solubilization. Factors affecting solubility.

1. Particle size. 4. Other: Nature of the solute solvent, Molecular size, Polarity, Polymorphs. 1.5.2.1 Absolute bioavailability and Relative bioavailability. Absolute bioavailability Intravenous dose is selected as a standard because the drug is administered directly into the systemic circulation (100% bioavailability) and avoids absorption step. Networking Papers! Intramuscular dose can also be taken as a standard if the drug is poorly water soluble. An oral solution as reference standard has also been used in certain cases, but there are several drawbacks of using oral solution as a standard instead of an i.v. dose. Relative or comparative bioavailability. It is also termed as comparative bioavailability. It is denoted by Fr.

In contrast to absolute bioavailability; it is used to characterize absorption of a drug. 1.5.2.2 Methods for baker thesis enhancement of bioavailability. As per definition of bioavailability, poor permeability through the biomembrane owing to papers inadequate partition coefficient or lipophilicity or large molecular size such as that of protein or peptide drugs are poor bioavailable drugs. Both poor solubility and permeability of drug is our daughters ourselves depends upon its physicochemical property. Biopharmaceutical Classification System (BCS) Based on social papers intestinal permeability and solubility of drugs, Amidon et al., developed Biopharmaceutical Classification System (BCS) which classify drugs into one of the four groups. Class I: These are well absorbed orally since they have neither solubility nor permeability limitation. Class II: Shows variable absorption owing to solubility limitation. Class III: also shows variable absorption owing to permeability limitation. Class IV: are poorly absorbed orally owing to baylor admissions both solubility and social networking thesis papers permeability limitation. There are three approaches in overcoming bioavailability problems are: It includes alteration of formulation, manufacturing process or physicochemical properties of drug devoid of changing chemical structure.

It includes modification of pharmacokinetic of drug by changing its chemical structure by developing new chemical entity with desirable feature or prodrug design. 1.5.2.3 By enhancing drug solubility or dissolution rate: 3. Supercritical fluid recrystallization. 4. Spray freezing into liquid. 5. University! Evaporative precipitation into aqueous solution. 6. Use of surfactants. 7. Use of salt forms. 8. Use of precipitation inhibitors. 9. Alteration of pH of drug microenvironment.

10. Thesis! Use of amorphous, anhydrates, solvates and metastable polymorphs. 11. Solvent deposition. 13. Selective adsorption on insoluble carriers. 14. Solid solution. 15. Ncea Level Writing Exemplars! Eutectic mixture. 16.

Solid dispersion. 17. Molecular encapsulation with cyclodextrin. 1.5.2.4 By enhancing drug permeability across biomembrane. 1. Lipid technology. 3. Penetration enhancers.

1.5.2.5 By enhancing drug stability. 1. Enteric coating. 3. Use of metabolism inhibitors. 1.5.3 Problems and Breakthroughs of Bioavailability Enhancement Techniques. When poor wetting properties and difficulties in social, processing of level creative powders are problems reduction in particle size can not applicable in such conditions. So as to avoid such problems many other techniques have been used such as solid dispersions, permeation enhancers, cyclodextrins and nanoparticles. In fact, in some special cases, such approaches have been doing well.In the technique of reducing the size of particles, there is affinity for agglomeration of particles due to high surface charges on small discrete particles. 1.5.4 Lipid based drug delivery. Ideal properties of Lipid based formulations. 1. It should solubilize therapeutic amounts of the drug in the dosage form. 2. Networking Thesis! It should maintain adequate drug solubility over ourselves, the entire shelf-life of the drug product (generally 2 years) under all anticipated storage conditions.

3. It should provide adequate chemical and physical stability for the drug and formulation components. 4. It must be composed of approved excipients in safe amounts. 5. It should adapt to the digestive processes of the GI tract such that digestion either enhances or maintains drug solubilization. 6. It should present the drug to the intestinal mucosal cells such that absorption into the cells and into the systemic circulation is optimized. 2.0 NEED FOR STUDY OBJECTIVE. Oral route is the most convenient and preferable route for the administration of social networking thesis drugs but the essays in america problems is occurs due to the low solubility of drugs. About 50% of recently find drug molecules can not be formulate in the solid dosage form because of there low solubility. The need of this study was to increase the thesis solubility of poorly soluble compound. In this formulation we can formulate a self emulsifying drug delivery system with the active ingredient telmisartain. Telmisartain practically water insoluble drugs. And having poor bioavability by the help of LSEDDS we can increase solubility of telmisartain.

3. LITRATURE SURVEY. 1. . Saritha,D. et al. (2014) Prapration a stable formulation for self emulsifying drug delivery systems (SEDDS) in order to enhance the solubility, release rate, and oral absorption of the poorly soluble drug, indomethacin. Our Daughters Ourselves! Based on the solubility of indomethacin in oil, surfactant and cosurfactant, pseudo-ternary phase diagrams were developed in 1:1, 1:2, 2:1, 1:3, 3:1, 4:1 ratio for SEDDS composed of labrafil, cremophor EL and transcutol P. Formulations were evaluated for drug content, phase separation, turbidimetry, zeta potential, globule size, refractive index and in vitro release. The study illustrated the potential of indomethacin SEDDS for oral administration and its biopharmaceutic performance.33. 2. Damineni,S et al (2014) developed self emulsifying drug delivery system of ibuprofen to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to traditional oral formulations to social papers improve bioavailability. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively.

Formulation development and screening was done based on results obtained from essays on injustice in america phase diagrams and characteristics of resultant microemulsions. The developed SEDDS were evaluated for droplet size analysis, zeta potential, polydispersibility index, viscosity, refractive index, % transmittance, drug content and in vitro diffusion profiles.34. 3. Kumar,S. et al (2014) in networking thesis, this article we have study upper surface of SEDDS. The main advanced topic in our daughters, this article is social networking papers solidification process of LSEDDS and the development of ncea 1 english creative exemplars solid SE dosage forms.at the last find he prolems of the system and social networking thesis papers solve it.35. 4. Reddy,M. et al (2014) In this article we have conclude, today huge numbers of formulation avalables for on injustice the increasing poor water solubility of drugs , dissolution rate and bioavailability of social papers insoluble drugs. One of the promising techniques is Self’Micro Emulsifying Drug Delivery Systems (SMEDDS).

Liquid SEDDS were prepared using LLWL 1349, Labrafac PG as oils and cremophor EL, cremophor RH40 as surfactants and labrasol, transcutol HP as co-surfactants. Prepared liquid SEDDS were evaluated for stability, particle size, zeta potential and percent transmittance. Selected liquid formulations were converted to solid SEDDS by adsorbing onto a solid carrier Neusilin. Ncea Level 1 English Creative Exemplars! Prepared solid SEDDS were evaluated for networking flow properties and in-vitro drug release studies. Ncea Level 1 English Exemplars! Results proved that prepared solid SEDDS have good flow properties and improved drug solubility and dissolution profiles (99.95%) when compared to pure efavirenz.36.

5. Amrutkar,C. et al (2014) The aim of the networking thesis papers present study is to improve solubility and hence bioavailability of Rosuvastatin calcium using self nanoemulsifying drug delivery system (SNEDDS). University! self emulsifying property of social papers various oils was evaluated with suitable surfactant and co-surfactants. Ternary phase diagram was constructed based on Rosuvastatin calcium solubility analysis for optimizing the systems. The prepared formulation were evaluated for self emulsification time, dispersibility study, average globule size, Polydispersibility index (PDI). The globule size of ourselves optimized system was less than 100nm which could be an acceptable nanoemulsion range. The average globule size of the selected F2 SNEDDS formulation (Capmul MCM [20%], Tween 20 [40%] and PEG 200 [40%]) was 88.01nm. In vitro drug release studies showed remarkable increase in dissolution of F2 SNEDDS compared to marketed formulation.37. 6. . Choudhary,S.B. Networking Thesis Papers! et al (2014) revealed formulated and our daughters ourselves essay characterization solid self emulsifying drug delivery system (SSEDDS) of domperidone for filling into soft gelatine capsule.

Pseudo ternary phase diagrams were constructed and networking papers liquid SEDDS formulations were prepared which consists of essay oleic acid, tween 20 and propylene glycol as oil phase, surfactant and cosolvent respectively. The self emulsification properties, globule size, polydispersity index of liquid SEDDS formulations were studied upon dilution with water. Social Networking Thesis! The solid SEDDS was prepared by in indian uni spray drying method and kneading method using Aerosil 200 as solid career. The solid state characterization of the solid SEDDS was performed by SEM, DSC, and networking thesis papers X-ray powder diffraction. Baylor University Admissions Essay! The results from this study demonstrate the potential use of SEDDS as a means of networking thesis improving solubility, dissolution, and concomitantly the bioavailability.38. 7. .Gikwad,S. et al. Thesis Machine! (2012) A reaserch on self-emulsifying drug delivery system (SEDDS) to enhance the solubility of the poorly water-soluble drug Orlistat. These drugs can be successfully formulated for oral administration, but care needs to be taken with formulation design to ensure consistent bioavailability.

Solubility of Orlistat was evaluated in various nonaqueous carriers that included oils, surfactants, and cosurfactants. Social Networking Thesis Papers! Pseudoternary phase diagrams were constructed to identify the self-microemulsification region. The self microemulsification properties, droplet size and thermodynamic stability of these formulations were studied upon dilution with water.38. 8. . Sachan,R. et al. (2010) To develop a formulation For the improvement of ourselves essay bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations dissolution rate which may improve therapeutic performance and drug loading capacity so as to social networking thesis papers develop alternative to traditional oral formulations to improve bioavailability. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively. Ourselves Essay! Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions.39. 9. Liu Y., et al., (2009) optimized and thesis papers characterized an oridonin SMEDDS formulation using central composite design. In this study effect of concentration of oil andsurfactant and co-surfactant ratio has been studied. Study concluded that, this model is thesis useful for optimization of SMEDDS formulation. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.40. 10.

Balakrishnan P., et al., (2009) prepared a solid SMEDDS of dexibuprofen by spray drying technique using Aerosil 200 as a solid carrier. After conversion in to social thesis solid form S-SMEDDS retains its self emulsification capacity. In-vitro drug release showed that, there was increase in drug release as compared to powder formulation. In-vivo study showed that increase in bioavailability. Study concluded that, in the form of Solid SMEDDS it retains all characteristics of liquid and it can become helpful solid dosage form.41. 11. Our Daughters Ourselves! Singh A. K., et al., (2009) prepared and evaluated SMEDDS of social networking thesis papers Exemestane using Capryol 90, Cremophore ELP, and research Transcutol P. They compared drug release with marketed formulation in different pH. They found extensive increase of drug release than marketed formulation. Social Thesis! They also compared absorption of drug with that of essays drug suspension. They found enhanced drug absorption from SMEDDS.

Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of thesis papers poorly water soluble drug.42. 12. Shaji J., et al., (2008) formulated and evaluated SMEDDS of Celecoxib. They optimized formulation using 33 factorial design. Particle size was taken as response variable. Study showed that, concentration of different components showed prominent effect on particle size and appearance of dispersion. Sheridan Baker Thesis Machine! They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.43.

13. Atef E., et al., (2008) formulated and social networking evaluated SMEDDS of phenytoin and compared its relative bioavailability with marketed formulation. Results showed that, extensive increase in drug release form SMEDDS as compared to our daughters ourselves that of marketed suspension. Also in-vivo study showed improvement in bioavailability. Study concluded that, SMEDDS is promising formulation to increase drug release as well as bioavailability of social thesis papers poorly water soluble compounds In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.44. 14. Fatouros D. G., et al., (2008) studied dynamic lipolysis model for plant hormone absorption of drug from SMEDDS formulations. They also studied IVIVC with the help of neuro-fuzzy networks.

Study concluded that, in evaluation of SMEDDS for prediction of in-vivo behavior in-vitro dynamic lipolysis model is a possible means.45. 15. Networking Thesis Papers! Shikov A., et al., (2008) Prepared and characterized SMEDDS of flavonoids. Prepared SMEDDS formulation was evaluated for self emulsification capacity, droplet size and for bioavailability. Results showed that, They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of enhancing solubility, absorption and hence bioavailability of university poorly water soluble drug. there was 2-5 fold increase in bioavailability as compared to social networking thesis papers flavonoid in powder form.46. 16.

Woo J. S., et al., (2008) developed SMEDDS of Itraconazole and studied and compared in-vivo study in human volunteers with marketed formulation having double dose. Study concluded that, there is essay extensive increase in bioavailability with reduced food effect by networking thesis SMEDDS formulation as compared with marketed formulation. University Admissions Essay! They found enhanced drug absorption from SMEDDS. Study concluded that, SMEDDS have potential of networking enhancing solubility, absorption and hence bioavailability of poorly water soluble drug.47. 17. Mandawgade S. D., et al., (2008) developed SMEDDS using natural lipophile as oil phase and also compared its performance with synthetic oils. For this study beta-Artemether was used as drug.

Oil was previously evaluated for toxicity studies. Prepared SMEDDS was evaluated for globule size, in-vitro and in-vivo study. Study concluded that, performance of natural lipophiles is better than that of commercially available synthetic oils hence can be used in SMEDDS as it is safe.48. 18. Yi T., et al., (2008) developed a controlled release solid SMEDDS of nimodipine using HPMC. They have prepared batches by sheridan thesis mixing drug with HPMC and another batch by papers dissolving drug and HPMC in the SMEDDS. Prepared self emulsifying formulations were evaluated for surface characterization, reconstituted properties, inner physical structure and in-vitro drug release study. Study concluded that, It can be possible to sheridan formulate controlled release formulations of poorly water soluble drug by SMEDDS using high viscosity grade HPMC.49. 19.

Yi T., et al., (2008) developed a S-SMEDDS of nimodipine. Prepared S-SMEDDS was evaluated for in-vitro and in-vivo absorption study. They have studied effect of dilution media and enzymatic digestion on solubilization of drug .Results showed that, there is faster dissolution rate of drug from S-SMEDDS than that of conventional tablet and enhancement of absorption as compared to thesis liquid SMEDDS. . On Injustice! Prepared SMEDDS was evaluated for globule size, in-vitro and in-vivo study. Study concluded that, performance of natural lipophiles is better than that of commercially available synthetic oils hence can be used in SMEDDS as it is safe. Study concluded that, S-SMEDDS can become constructive dosage form for thesis papers oral use.50. 20. Abdalla A., et al., (2008) Study concluded that, S-SMEDDS can become constructive dosage form for ncea level 1 english creative writing oral use. developed self emulsifying formulation in the form of pellets by extrusion and spheronization technique. In. this study they found that, droplet size decreases after dilution. Study concluded that, solubilzation depend on concentration of secretions like bile salts and phospolipid.

SMEDDS can besuccessfully transformed into pellets form and can become another method to encapsulate material into hard gelatin capsule.51. 21. Social! Lu J. L., et al., (2008) developed SMEDDS of 9NC to enhance bioavailability and plant paper anticancer effect. They prepared microemulsion of 9NC and characterized for citotoxicity and bioavailability study. Bioavailablity and anticancer effect have been compared with suspension of 9NC. Study concluded that, antitumor activity has been enhanced in social thesis, the form of SMEDDS.52. 22. Patel D., et al., (2007) developed SMEDDS of Acyclovir. Prepared formulations were evaluated for different parameters.

Absorption of drug from SMEDDS was compared with plain drug solution. Politics Thesis In Indian! Results showed that, there was 3.5 fold increases in bioavailability by SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach. . Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in plasma triglycerides when compared with reference formulation of drug suspension. Study concluded that, there was better biopharmaceutical performance of drug from SEDDS.53. 23.

Cirri M., et al., (2007), formulated oral liquid spray formulation of xibornol using SMEDDS. Prepared formulations were evaluated for rheological, stability, SAXS and in-vivo study. The study found that, SMEDDS can be used to prepare stable and effective oral liquid spray formulation. Absorption of social thesis drug from SMEDDS was compared with plain drug solution. Results showed that, there was 3.5 fold increases in ncea level 1 english creative writing, bioavailability by SMEDDS. Study concluded that, bioavailability of drug can be enhanced using SMEDDS approach.54.

24. Patil P., et al., (2007) formulated a SEDDS for simvastatin. Prepared SEDDS was evaluated for turbidometric analysis, particle size, in-vitro drug diffusion and in-vivo study in social networking thesis papers, rat. Plant! Results showed that there were 5 fold reductions in plasma cholesterol and 4 fold reductions in plasma triglycerides when compared with reference formulation of drug suspension. Study concluded that, there was better biopharmaceutical performance of drug from SEDDS.55. 25. Thesis! Patel A. R., et al., (2007) formulated and evaluated SMEDDS of fenofibrate. Ourselves Essay! From solubility study of drug in networking, different components oil, surfactant and co-surfactant were selected and pseudo ternary phase diagram were constructed. From this SMEDDS were prepared and evaluated for on injustice in america thermodynamic, dissolution, stability study and lipid lowering capacity. Study concluded that, SMEDDS can improve dissolution rate and hence bioavailability of drug which become substitute for oral drug delivery system. Thesis! Study concluded that, there was better biopharmaceutical performance of research paper drug from SEDDS.56.

26. Shen H., et al., (2006) prepared and networking evaluated SMEDDS of atorvastatin using Labrafil, PEG and Cremophor RH40. From solubility study of drug in different components oil, surfactant and co-surfactant were selected and pseudo ternary phase diagram were constructed. SMEDDS capsule of atorvastatin were prepared and on injustice in america drug release were studied and papers compared with conventional tablet. Results showed that release of drug was much higher from SMEDDS capsule than that of tablet. Study concluded that, bioavailability of drug can be enhanced using SMEDDS capsule than conventional tablet. controlled release of drug can be obtained from lipid formulations in essay, tablet dosage form.57.

27. Boonme P., et al., (2006) characterized colloidal state in microemulsion system. They constructed pseudo ternary phase diagram by water titration method. different process parameters affect dissolution rate of drug from thesis papers tablet. Study concluded that, controlled release of drug can be obtained from lipid formulations in tablet dosage form. Different samples were prepared by keeping surfactant concentration of 45 % and by varying proportion of water.

Prepared samples were evaluated for appearance, viscosity, conductivity, DSC, SEM and NMR. Study concluded that, if composition has 15 % of politics thesis in indian uni water, it contain reverse micelles, W/O emulsion obtain if it contain 15-30 % of water and it gives O/W emulsion of social it contain more than 35 % of water.58 28. Nazzal S., et al., (2006) evaluated different process parameters which affect release of drug from thesis in indian uni SNEDDS in tablet dosage form. Solid preparation was prepared to study absorption of social thesis drug in rat and plant paper dog. Prepared tablets were evaluated for dissolution and stability studies. Results showed that, different process parameters affect dissolution rate of drug from tablet. Study concluded that, controlled release of drug can be obtained from lipid formulations in tablet dosage form.59 29.

Wu W., et al., (2006) prepared SMEDDS of silymarin. From solubility study of social thesis drug Tween 80, ethyl alcohol and ethyl linoleate were selected as formulation components Solid preparation was prepared to study absorption of drug in rat and dog. Results showedthat Florite RE gives more absorption of drug both in rat and dog. Results showed that, there is increase in particle size as increase in drug loading in formulation. Drug release was much higher than that of crude drug powder. Essays! Study concluded that by papers using SMEDDS bioavailability of silymarin can be enhanced.60 30.

Ito Y., et al., (2005) prepared solid formulation of gentamicin using different adsorbents and surfactant to level 1 english enhance absorption of drug. Social! Florite RE, Neusilin US2 and Sylysia 320 were used as adsorbents and sheridan baker Labrasol was used as surfactant. Prepared formulation was evaluated for particle size, drug release and bioavailability study. Results showed that, there is increase in particle size as increase in social, drug loading in formulation Study concluded that by using adsorbent and surfactant system oral solid formulations can be prepared so as to increase absorption of poorly absorbable drug.61 31. Sha X., et al., (2005) studied effect of charge and dilution on TEER and permeability of mannitol by ourselves essay formulating SMEDDS using Labrasol and also studied effect of dilution of surfactant on networking ZO-1 and F-actin. Our Daughters Ourselves! Study concluded that, SMEDDS of both positive and negative charge containing Labrasol are capable of enhancing the networking thesis papers paracellular tramsport of mannitol across Caco-2 cell at different dilutions. , there was significant increase in rate and ourselves essay extent of absorption of social networking thesis drug as compared to capsule. On Injustice In America! It was also found that, there was 1.5 fold increases in bioavailability than tablet. Thesis! Study concluded that, SMEDDS can be beneficial for baylor university admissions oral delivery of thesis papers poorly water soluble drug such as simvastatin.62 32. Sheridan Baker Thesis! . Subramanian N., et al., (2004) developed and networking thesis optimized SMEDDS of Celecoxib using simplex lattice mixture design. Prepared SMEDDS were evaluated for Clarity, solubility, in-vitro dissolution and politics in indian in-vivo study. Results showed thatRelative bioavailability with capsule was found to be 132 %. Study concluded that, prepared formulation will reduce variability in networking papers, absorption and rate and gives rapid onset of action of in america drug.

It was also found that, there was 1.5 fold increases in papers, bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for university essay oral delivery of poorly water soluble drug such as simvastatin.63 33. Kang B. K., et al., (2004) prepared SMEDDS of simvastatin using Carpryol 90, Cremophor EL and Carbitol. Social Papers! Prepared formulations were evaluated for admissions essay Sustained drug release was achieved by using Silicon dioxide as gelling agent which retarded release of drug, in-vitro dissolution study and bioavailability study. Results showed that, in-vitro of drug was much higher that that of papers conventional tablet. Ncea Level Writing Exemplars! It was also found that, there was 1.5 fold increases in bioavailability than tablet. Study concluded that, SMEDDS can be beneficial for oral delivery of poorly water soluble drug such as simvastatin.64 34. Patil P., et al., (2004) formulated a gelled SEDDS of ketoprofen using Captex 200, Tween 80 and thesis Capmul MCM.

Sustained drug release was achieved by thesis using Silicon dioxide as gelling agent which retarded release of drug. Study concluded that, as concentration of gelling agent increases it increase droplet size of emulsion formed which helps in slowing drug diffusion. It was also found that, as concentration of co-surfactant increase drug release from dosage form also increases.65 35. Holm R., et al., (2003) importance of thesis papers this examined oral absorption and lymphatic transport of essay halofantrine in SMEDDS containing triglycerides, Sustained drug release was achieved by social papers using Silicon dioxide as gelling agent which retarded release of drug. Maisine-35-1 and Cremophor EL. Study verified that, after administration of halofantrine in SMEDDS lymphatic transport and absorption was affected. Study concluded that, by using differentstructure of triglycerides it is achievable to baylor enhance lymphatic transport of networking papers compound without affecting its availability.66 36. Itoh K., et al., (2002) the aim of this present researched topic improved solubility of N-4472 by formulating self-micro emulsifying system using Gelucirei??i?? 44/14, HCO and SDS. Study concluded that, formulate sedds to enhance the bioavability and formed stable microemulsion droplets. SDS showed vital role in stability of microemulsion droplets.67 37.

Agarwal V., et al., (2000) investigated effect griseofulvin SMEDDS addition to silica and ncea creative writing exemplars silicate on flow properties and in-vitro drug release. Results showed that, increase in surface area increases dissolution of drug. Study concluded that, nature and amount of adsorbent affect flow properties and dissolution of social drug in SMEDDS. Level 1 English Writing Exemplars! In-vitro drug release showed that, there was increase in drug release as compared to powder formulation.68 38. Kim H. Networking Thesis! J., et al., (2000) developed SMEDDS of idebenone using Labrafil 2609, Labrasol. Transcutol and Plurol oleique WL1173 so as to enhance bioavailability by the increasing the solubility of the machine poorly water solublr drug. Results showed that, in-vitro dissolution rate of drug were increased 2 folds than that of tablet. Study concluded that, SMEDDS can be used as substitute for traditional oral formulations to social thesis enhance bioavailability of on injustice idebenone.69 39. Chen G. L., et al., (1996) the importance of this present researched study was validated bioanalytical method for social thesis papers determination of Verapamil from plasma by essays in america HPLC for pharmacokinetic study of Verapamil. They also studied sensitivity, specificity, linearity, accuracy, precision and sample stability of social thesis papers method. For the purpose of sheridan baker sedds evaluation.70 40.

Shah N. H., et al., (1994) the aim of this study was investigated emulsification efficiency of polyglycolyzed glycerides (PGG) and polyethylene glycol (PEG). They prepared SEDDS using different concentrations of PGG as emulsifiers,oils and different type of surfactant and thesis co-surfactant. Neobee M5 and hormone paper Peanut Oil were selected as oil. Drug having good solubility in oil was selected for this study. Study showed that, PGG can be used as emulsifier for preparation of papers SEDDS.71 MATERIAL METHOD 4. MATERIAL AND METHOD 4.1 MATERIALS Table 4.1: List of materials with sources S. Politics Thesis In Indian Uni! No. Materials Source 1. Social! Telmisartan Skymap Pharmaceuticals, Roorie 2. Tween 80 Loba chemic laboratory regents Mumbai 3. PEG 400 Nasco laboratory 4. Methanol Loba chemic laboratory regents Mumbai 5. Hydrochloric acid Loba chemic laboratory regents Mumbai 6. Orange oil Burgone laboratory Mumbai Table 4.2: List of equipments with make S. No. Admissions Essay! Equipment Make 1. Analytical balance Fuji electronic balance 2. Melting point apparatus Jyoti digital auto melting apparatus 3. UV – Spectrophotometer Jasco japan-v630 4. Social Networking! Dissolution apparatus Jyoti standard dissolution apparatus 5. FTIR Jasco-japan FT/IR/4100 7. mixing Jyoti lab gwl. Ourselves Essay! INDIA 8. Hot air oven Jyoti lab gwl.

INDIA 9. Water bath Jyoti lab gwl.INDIA 4.1.1 Drug profile: Telmisartan72 Telmisartan is thesis 4’-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. Structural formula ‘ Figure 3.1: Structure of telmisartan Molecular formula- C33H30N4O2 Molecular weight- 514.6 Definition 4’-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1- yl]methyl]biphenyl-2-carboxylic acid. Baylor Admissions! Content: 99.0 per cent to social thesis 101.0 per cent (dried substance). Category: Antihypertensive. University Admissions! Dose: 20 to 80 mg. Half life: 24 hrs. Appearance: White or slightly yellowish, crystalline powder. Solubility: Practically insoluble in water, slightly soluble in methanol, sparingly soluble in methylene chloride.

It dissolves in 1 M sodium hydroxide. It exhibits polymorphism. Melting point: 261 ‘ 263oC. Storage: it should be stored at room temperature (15 – 30 i??i??C), away from moisture and thesis light. Mechanism of action: It is an baylor university admissions, angiotensin II receptor antagonist. Social Thesis! Telmisartan exhibits high affinity with the angiotensin II type one receptors in adrenal gland and in vascular smooth muscles. It works by binding to the angiotensin II receptor. It inhibits the action of angiotensin which is a vasoconstrictor.

Angiotensin also stimulates the synthesis and release of aldosterone. By blocking the university essay vasoconstrictor effect of the angiotensin and blocking the aldosterone, Telmisartan reduces the social papers systemic vascular resistance. Pharmacokinetics: Absorption: After the level writing oral administration peak concentrations (Cmax) of telmisartan are attained in 0.5 to 1 hour. Ingestion with food slightly decreases the social papers bioavailability of Telmisartan. Politics! Absolute bioavailability is dose dependent. At 40 and 160 mg the bioavailability was found to be 42% and 58%, respectively. Thesis! Distribution: Binding with plasma proteins is constant with the on injustice recommend doses. Social Networking! It is highly binding with the plasma proteins (more than 99.5 %).

It has a volume of distribution of around 500 L. Metabolism: Telmisartan is metabolized by forming a pharmacologically inactive compound acyl glucuronide by our daughters ourselves essay conjugation. The only identifiable compound in the human plasma and networking urine is the glucuronide. Our Daughters Essay! Elimination: Telmisartan has a half life of networking thesis 24 hour and total plasma clearance of more than 800 mL/min. More than 97% of the thesis uni orally/IV administered telmisartan is eliminated in the feces via biliary excretion, unchanged. Uses: It is social networking thesis used to treat high blood pressure (hypertension). Thesis In Indian Uni! Adverse effects: The common reported adverse effects of telmisartan are upper respiratory tract infection (URTI) (7%), Back pain (3%), Diarrhea (3%), Myalgia (3%), and Sinusitis (3%).

Some rare adverse effects (1%) are abnormal ECG, anemia, angina, angioedema, bradycardia, eczema, epistaxis, gout, and hypercholesterolemia. Drug interactions: Telmisartan has found interacting with several drugs such as, benazepril, benazepril, benazepril, benazepril, benazepril, and papers benazepril etc. Caution is advised when combination will be used. Dosage forms: It is commonly used in the form of tablets of 20, 40, and 80 mg. 4.1.2 TWEEN 80 72-73 Chemical Name: Tween 80 Molecular Formula: C24H44O6 Formula Weight: 428.600006103516 Tween 80 Property Boiling point- 100i??i??C. Dencity – 1.08 g/mL at 20 i??i??C. Vapour pressure- 230 i??i??F. storage temp. : Store at RT. From- viscous liquid. Water Solubility : 5-10 g/100 mL at 23 i??i??C. EPA Substance Registry System: Sorbitan, mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.(9005-65-6)

Tween 80 Chemical Properties,Usage,Production. Yellow to amber liquid. Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and writing exemplars bitter taste. Air Water Reactions.

Tween 80 is incompatible with strong alkalis and oxidizers. Tween 80 is probably combustible. 4.1.3 ORANGE OIL 72-73:- It was the important and essincial oil can be produse by networking papers the cells in the fruits of oranges. Plant Hormone Paper! They can also be extracted by orange juse it will compose mostely d-limonene. That will be extract to the oil by distillation. Odour- fresh and tangy smell, Coloue- yellow to orange in color. Self life- approximately 6 months.

Origin of Sweet orange oil. This evergreen tree has dark green leaves and white flowers and social papers bright orange round fruit with roughish skin. The trees are native to China, but are now cultivated extensively in essays on injustice, America. 1. It can be used many Curacao type liqueurs. 2. for the flavoring of food. 3. drink and social networking thesis confectionery. 4. when added to furniture polish. 5. 1 English Creative Writing! helps to protect against damage from papers insects. The orange oil are extracted by cold-pressing and yields 0.3 -0.5 %. It can also use for the medicinal perpose that will gives several therapeutic actions are antiseptic, anti-depressant, antispasmodic, anti-inflammatory, carminative, diuretic, cholagogue, sedative and tonic. The main chemical components of baylor university admissions essay orange oil are a-pinene, sabinene, myrcene, limonene, linalool, citronellal, neral and geranial.

1. It is social thesis a safe non-toxic, non-irritant and non-sensitizing oil, 2. yet care must be taken with it since it can have a phototoxic effect. 3. It should therefore preferably not be applied before going out into sunlight for prolonged periods. Iupac name – polyethylene glycol. – 90.0 cst at 25 i??i??C, 7.3 cst at plant hormone research paper, 99 i??i??C.

PEG 400 properties. 1. (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. 2. It is a clear, 4. Social Networking! viscous liquid. 5. Due in part to its low toxicity, PEG 400 is widely used in a variety of hormone paper pharmaceutical formulations. 1. PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.

2. PEG 400 is strongly hydrophilic. 3. Social! The partition coefficient of PEG 400 between hexane and sheridan baker thesis machine water is 0.000015 (log ), indicating that when PEG 400 is mixed with water and hexane, 4. there are only 15 parts of PEG 400 in the hexane layer per 1 million parts of PEG 400 in the water layer.[1] PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons. 4.2 Preformulation studies 72,73,74,75. To develop a safe, stable and therapeutically effective dosage form, preformulation studies are necessary to perform. The preformulation studies, which were performed in this project, include identification of drug, melting point analysis, solubility analysis, and quantitative estimation of drug.

4.2.1 Identification tests. ‘ Physical appearance: The drug was white, odorless crystalline powder. ‘ Melting point analysis: Melting point of telmisartan was determined by capillary method using melting point apparatus (Rolex- Digital melting point apparatus). ‘ FTIR study: Drug sample was vacuum dried for social thesis 12 h before IR studies. Baylor University! IR spectra of pure telmisartan, PEG 4000, mannitol and thesis solid dispersions of telmisartan were obtained by a Shimadzu IR Prestige-21 FT-IR spectrophotometer using KBr pellets. The scanning range used was 4000 to thesis machine 400cm-1.

The observed peaks were reported for thesis functional groups. 4.2.2 Loss on drying73-74. It was determined on 1 g drug by drying it in a hot air oven at 105oC. The weight was determined at level creative writing, 15 min intervals till the difference was not more than 0.5 mg. The total difference in weight should not be more than 0.5%. 4.2.3 Determination of ‘max 73. Accurately weighed sample of 10 mg of telmisartan was dissolved in 50 mL of methanol in networking papers, a 100 mL volumetric flask and then the volume was made up to 100 mL with methanol.

Then, 1 mL of ourselves this stock solution was pipetted into a 10 mL volumetric flask and volume was made up to the 10 mL mark with methanol. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). The same procedure was followed to thesis determine the ‘max in HCl buffer (pH 1.2). University Essay! The prepared solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu). To determine ‘max in water, accurately weighed 10 mg sample of telmisartan was dissolved in 50 mL of methanol in social thesis papers, a 100 mL volumetric flask and volume was made up to 100 mL with methanol. Then, 1 mL of this stock solution was pipetted into a 10 mL volumetric flask and research paper volume made up to the 10 mL mark with distilled water. The resulting solution was scanned between 200-600 nm using UV/Vis double beam spectrophotometer (UV-1700, Shimadzu, Japan). 4.2.4 Quantitative estimation of drug73-74. Drug was estimated in the range of 3-15 mcg/mL for thesis papers telmisartan in water (pH 7.0), HCl buffer (pH 1.2) and methanol.

Preparation of HCl buffer (pH 1.2): 50 mL of 0.2 M KCl was added in plant, a 200 mL volumetric flask then 85 mL of HCl solution (0.2 M) was added in the flask and networking papers volume was adjusted to 200 mL with distilled water32. 4.2.5 Construction of ncea 1 english exemplars calibration curve of telmisarta73. 4.2.5.1. Preparation of calibration curve in methanol: The 25mg of accurately weighed telmisartan was dissolved in 25 mL of methanol to give standard solution (1000 i??i??g/mL). Networking Thesis Papers! From this standard solution, 3 mL was pipetted out and volume was made up to 100 mL with methanol referred as stock solution of concentration 30i??i??g/ mL. In America! Aliquots of 1 mL, 2 mL, 3 mL, 4 mL and 5 mL of social thesis stock solution were pipetted out into separate 10 mL volumetric flask. The volume was made up to the mark with methanol.

This results in samples of 3, 6, 9, 12 and 15 ‘g/mL concentration, respectively. The absorbance of level 1 english exemplars prepared solution of telmisartan in methanol was measured at 296.5 nm in Shimadzu UV-1700 spectrophotometer against an appropriate blank. 4.2.5.2. Networking Thesis! Preparation of calibration curve in machine, HCl buffer (pH 1.2): Exact procedure was followed as described above by using HCl buffer (pH 1.2) instead of methanol. The absorbance was recorded at 296 nm. 4.2.6. solublity of telmisartain in different medium. Solubility of telmisartain was determine in networking thesis papers, the different medium by heand shaking method. 3.3 Formulation 76. 4.3.1 identification of microemulsion region : Determine solubility of telmisartain in different -2 medium then select three medium orange oil as oil, PEG 400 as surfactant and tween 80 as co-surfactant. Level Creative! Micro-emulsion region was identify by constructing pseudo ternary phase diagram with the help of different proportion of surfactant and co-surfactant (1:1, 2:1, 3:1). They are mix with oils at different proportion (1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, 9:1) and the complete mixture was titrate with water and noted the equbliurem point.

At which point the mixture will show clear. 4.3.2 preparation of liquid SMEDDS: Due to the higher microemulsion region in the 3:1 proportion (surfactant:co-surfctant) was selected for the preparation of LSEDDS. 1. Required amount of PEG 400 and tween 80 was take and mix with the help of stirrer until they compatibly mix. 2. Aquaretly weight telmisartain and take required amount of networking papers orange oil and mix il. 3. Drug mixture place on water bath until drug completely dissolve in oil. 4. Both the mixture are mix togather on in america the magnatic stirrer untill they are compleately mix and thesis papers form a isotropic mixture. 5. Store in the glass bottle.

Table 4.3 chemical requirements. Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg. 4.4 CHARACTERIZATION :76-77. 4.4.1 stability study :76. 4.4.1.1 heating cooling cycle: for the stability study of LSEDDS pass six cycle between hot and cool temperature (40c-450c) with storing not less then 48hrs at ncea 1 english, each temp. not seen any type of phase sapration. 4.4.1.2 centrifugation test: After passing heating cooling cycle it would be pass with centrifugation test. The sample of social networking thesis LSEDDS placed in centrifuge for 30min and show any type of precipitation. If not seen it would be go to the next stability test.

4.4.1.3 freeze thaw cycle: This test is again at baker thesis, cool and hot temperature (-210C to +250C) 48 hrs at social thesis papers, each temp. If the LSEDDS pass all the stability parameter means the system becomes stable. 4.4.2 cloud point measurement : 76-77. Liquid SMEDDS was diluted with distilled water at sheridan baker thesis machine, 250 times LSEDDS : distill water(1:250), placed in a water bath and networking thesis papers its temperature was increased slowely-2.

Cloud point was measured as the temperature at which there was a sudden appearance of cloudiness visually. 4.4.3 solubility test .77-78. Solubility of LSEDDS was determine at buffer solution at our daughters ourselves, 1.2ph, 7.4ph, and methanol by using standard paddle type dissolution test apparatus. 4.4.3.1 Preparation of HCl buffer (pH 1.2): 50 mL of 0.2 M KCl was added in a 200 mL volumetric flask then 85 mL of HCl solution (0.2 M) was added in the flask and networking thesis volume was adjusted to 200 mL with distilled water. 4.4.3.2 Buffer pH 7.4: Mix 50 mI of essays in america solution containing 1.944 per cent w/v ofsodium acetate and 2.946 per networking thesis papers, cent w/v of barbitone sodium with 50.5 mI of 0.1 M hydrochloric acid, add 20 mI of an 8.5 per cent w/v solution of sodium chloride and dilute with water to 250 mI.

4.4.4 efficiency of self emulsification :76-77. Using USP- type-II dissolution test apparatus (Veego VDA-8DR). 1 mL of Liquid SMEDDS was added drop wise to 200 ml of 0.1 N HCl at 37i??i??C. Politics Thesis In Indian Uni! agitate using by using standard stainless at rotating paddle at 60 rpm. SMEDDS assessed visually according to the rate of papers emulsification and final appearance of the emulsion. 4.4.5 Robustness to dilution :76. it can be studied by by diluting LSEDDS at essays on injustice, different concentration with distill wate. 1. Prepare HCL buffer solution PH 7.4, PH 1.2. 2. Prepare dilution with both the solution at social papers, following concentration. 3. Store for 12 hrs.

4. Observe any type of phase saperation or pracipation. 4.4.6 % transmittance :76. For the determination of % transmittance take. 1. 1ml of LSEDDS and diluted till 100ml with distilled water. 2. Scan this sample in the uv spectroscopy. 3. observe any type of turbidity and % transmittance. 4.4.7 Dye solubility test : 76. This test can be perform for the conformation of ourselves oil in water nature of LSEDDS by observing sopntenious dispersion. 1. Take water soluble dye and sufficient quantity of LSEDDS. 2. Rapidly incorporate dye into social networking thesis papers the system. 4.4.8. in vitro drug release:76-77.

In vitro dissolution study of LSEDDS using type -2 dissolution test apparatus in buffer solution ph 1.2, ph 7.4 at 370 c. 4.4.8.1 Drug release in buffer solution at thesis uni, 1.2 PH :- 1. Prepare buffer solution 1.2 PH by the help of networking thesis indian pharmacopeia. 2. Our Daughters Ourselves Essay! Fill in the type-2 dissolution test apparatus upto 900ml . 3. Palce 2ml sapmle of LSEDDS in the apparatus. Start the assumbaly. 4. Social Thesis Papers! Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min. 5. The all sample was filtered with whatmant filter paper.

And dilute upto 10ml. 6. If there concentration is high then take again 1ml to in america all the samples and and dilute again upto 10ml. 7. Papers! The sample was scan into the uv spectroscopy at 296nm. 4.4.8.2 Drug release in buffer solution at essay, 7.4 PH :- 1. Prepare buffer solution 7.4 PH by the help of indian pharmacopeia. 2. Thesis Papers! Fill in ncea writing, the type-2 dissolution test apparatus upto 900ml . 3. Palce 2ml sapmle of LSEDDS in the apparatus. Start the social networking papers assumbaly. 4. Essays In America! Take sample after regular interwal. 5 min, 10 min,15 min,30 min,45 min,60 min,90 min,120 min.

5. The all sample was filtered with whatmant filter paper. And dilute upto 10ml. 6. If there concentration is high then take again 1ml to all the samples and social networking papers and dilute again upto 10ml. 7. Politics In Indian Uni! The sample was scan into the uv spectroscopy at 296nm. 4.4.9 drug contant:76-77-78-79. drug content of social thesis LSEDDS should be determine by diluting 1 ml sample of LSEDDS with distill water.

Take there absorbance in baylor admissions, uv-spectroscopy at296nm. 1. Take 1ml sample of LSEDDS and dilute with distill water upto 100ml. 2. If the concentration of networking thesis sample was high then furthers 1ml sample dilute with distill water upto 10ml. 3. Scan this sample in uv-spactroscopy. 4. Calculate there percentage by the help of leaner line equation. RESULT AND DISCUSSION. Table 5.1: Melting point of on injustice telmisartan.

S. Social Networking Papers! No. Melting point Result. 5.1 LOSS ON DRYING: The results were within the sheridan acceptable limit which is networking thesis papers 0.5%. Table 5.2: Loss on drying. S.No. Time (min) Weight (mg) Difference in 1 english, weight (mg)

Total difference 2.9. 5.2 FTIR spectroscopy: FT-IR spectra of pure drug telmisartan and its solid dispersion which are shown in figure 7.1 and 7.4. Social Networking Thesis Papers! There was not any significant interaction found between drug and on injustice in america carriers which confirms the stability of drug in the formulation. Table 5.3: Major peaks observed in FTIR spectrum of telmisartan. S. No.

Standard peak Observed peak Comments. 1. 3059.1cm-1 3080 cm-1 C-H stretching (aromatic) 2. 2958.8-2868.15 cm-1 2870-2738.92 cm-1 C-H stretching (aliphatic) 3. 1697.36 cm-1 1687.71 cm-1 C=O stretching. 5. 1521.84-1458.18 cm-1 1462.04 C=C stretching ring. Figure 5.1: FT-IR spectra of pure telmisartan.

5.4 LEMDA MAX OF TELMISARTAIN IN DIFFERENT SOLVENT SYSTEM : Table 5.4: Solvent systems, their parameters and values. S.No. Solvent system Parameters Values. 1. Methanol i??i??max 296.5 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.050x + 0.007. Regression coefficient (R2) 0.999. 2. Buffer 7.4 i??i??max 298 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.043x + 0.004.

Regression coefficient (R2) 0.999. 3. HCl buffer (pH 1.2) i??i??max 296 nm. Beer’s law range 3 – 15 mcg/mL. Regression line equation y = 0.046x + 0.007. Regression coefficient (R2) 0.999. 5.5 CALIBRATION CURVE OF TELMISARTAN IN DIFFERENT SOLVENT SYSTEM. Table 5.5: Calibration curve of telmisartan in HCl buffer pH 7.4 and HCl buffer pH 1.2 at ‘max 298 nm and 296 respectively. S.No. Concentration (i??i??g/mL) HCl buffer pH 7.4 HCl buffer pH 1.2. Absorbance Regressed Absorbance Absorbance Regressed Absorbance.

2. 3 0.139 0.133 0.153 0.145. 3. 6 0.270 0.262 0.294 0.283. 4. 9 0.401 0.391 0.423 0.421. 5. 12 0.537 0.520 0.567 0.559. 6. 15 0.657 0.649 0.706 0.697. S.No.

Concentration (i??i??g/mL) Methanol. Absorbance Regressed Absorbance. Table 5.6: Calibration curve of telmisartan in methanol at social networking thesis papers, ‘max 296.5 nm. Figure 5.2: Calibration curve of telmisartan in buffer 7.4 ph at 298 nm. Figure 5.3: Calibration curve of telmisartan in HCl buffer pH 1.2 at 296 nm. Figure 5.4: Calibration curve of ncea level creative writing telmisartan in methanol at networking thesis, 296.5 nm.

5.6 SOLUBILITY OF TELMISARTAIN : Table 5.7: solubility of telmisartain in different medium. S.NO. MEDIUM SOLUBILITY. 1. Water Insoluble. 2. Hcl Springly soluble. 3. Methanol soluble. 5. PEG400 Soluble. 6. Tween 80 Springly soluble.

7. Tween 20 Springly soluble. 8. Span 80 Springly soluble. 5.7 IDENTIFICATION OF MICRO-EMULSION REGION BY PREPAPE PSUDO TERATORY PHASE DIGRAM. In this formulation preportion of surfactant and plant hormone co surfactant is 1:1. Table 5.8: identification of social networking thesis micro-emulsion region. SMIX : OIL END POINT. In this formulation preportion of surfactant and co surfactant is 2:1. Table 5.9: identification of micro-emulsion region.

SMIX : OIL END POINT. In this formulation preportion of surfactant and co surfactant is ncea level 1 english 3:1. Table 5.10: identification of micro-emulsion region. Smix : OIL END POINT. Result- Best micromulsion was found to social networking papers be In formulation 3 at 5:5 proportion of oil and mixture of surfactant and co-surfactant denoted as smi. 5.8 FORMULATION OF LIQUID-SELF EMULSIFYING DRUG DELIVERY SYSTEM (LSEDDS). 5.8.1 chemical requirement: Table 5.11: chemicals requirements . Orange oil 50 ml. Tween 80 12.5 ml. Telmisartain 2000 mg/2gm. 5.9 EVALUATION OF LSEDDS.

5.9.1 stability study. Physical stability was important parameter in the emulsion system it can be affected the performance of the creative system, it can be occurs due to the precipitation of drug. Due to the poor stability of system bioavability of social networking thesis drug also affected. For the thermodynamic stability study of on injustice in america LSEDDS was perform by following perameater. 1. Heating cooling cycle.

2. Thesis! Centrifugation test. 3. On Injustice In America! Freeze thaw cycle. When system can not show any type of phase separation during heating cooling cycle then syatem can be tested in the centrifugation for the drug pricipation then apply freeze thaw cycle for the stress test. 5.9.1.1 heating cooling cycle : 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. 40c No separation.

450c No separation. 40c No separation. 450c No separation. 40c No separation. 450c No separation. Table 5.12: six cycle of heating cooling temp. Result ‘ not seen any type of phase saperation. 5.9.1.2 Centrifugation test:

Result- LSEDDS was centrifuge for 30 min there was not seen any type of precipitation and phase saperation. 5.9.1.3 freeze thaw cycle. Table 5.13: three cycle of -210c to +250c. Cool temp. No change.

Hot temp. No change. Cool temp. No change. Hot temp. No change. Cool temp. No change. Hot temp. No change. 5.9.2 cloud point measurement. Table 5.14: Cloud point. Sample Cloud point.

Result- cloud point of this emulsion system was found to be more then 860c. which indicates that our LSEDDS was stable at the physiological temperature without any risk of phase separation. 5.9.3 solubility study: Table 5.15: solubility of LSEDDS. Medium Solubility time. Buffer solution PH 1.2 Less than 5min. Buffer solution PH Less than 5min. 0.1 N HCL Less than 5min.

Result ‘ solubility of this system was found to be less than 5min which indicates that the social networking formulation also use in the sustain release drug delivery system with maximum bioavability. 5.9.4 Efficiency of self-emulsification. Sample Efficiency of 1 english writing exemplars LSEDDS. 1 Less than 1min. 2 Less than 1min. 3 Less than 1min. Result ‘ this system rapidly form micro emulsion with in social thesis, 1min it was clear and appearance was slightly blush. 5.9.5 Robustness to dilution : Table 5.15: dilution with different solvents. Concentration Water Buffer solution.

PH 1.2 Buffer solution. 50 times No change No change No change. 100 times No change No change No change. 500 times No change No change No change. 1000 times No change No change No change. Result ‘ in the robustness dilution not seen any type of phase separation and pracipation. Result- % trasmittance of politics thesis in indian this system was found to be 93.5. 5.9.7. dye solubility test.

Result- type of emulsion was conform by social thesis using dye solubility test in which a water soluble colourfull dye rapid incorporate in the LSEDDS and hormone research paper observe. Which indicates that the continuous phase in this system is social networking water. so it was conform that the LSEDDS was o/w micro emulsion. 5.9.8 in-vitro drug release profile. 5.9.8.1 drug release in buffer solution PH1.2. Table 5.16 in-vitro drug release of in america SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 7.35 42.43. 15 min 11.63 61.36. 30 min 1.83 75.45.

45 min 18.64 83.33. 60 min 23.31 89.02. 90 min 27.15 95.26. 120 min 29.48 95.56. Figure 7.4 commulative % drug release of SEDDS and thesis papers plain telmisartain in baylor university essay, PH 1.2. 5.9.8.2 drug release in buffer solution PH 7.4.

Table 5.17 in-vitro drug release of SEDDS. % cumulative drug release. Plain drug LSEDDS. 10 min 11.38 47.39. 15 min 14.92 54.43. 30 min 19.61 73.13. 45 min 24.48 81.68. 60 min 28.29 90.83. 90 min 32.62 96.54. 120 min 33.46 98.12.

Figure 7.6 % commulative drug release of thesis papers LSEDDS and plan telmisartain in PH 7.4. 5.9.9 drug content estimation. Table 5.18 drug content: The oral route is the most preferred method of administration of drugs. Unfortunately, this route is not possible for essays 50% of currently marketed drug compounds due to social their low solubility in water and low oral bioavailability. We study that self-emulsifying drug delivery system (SEDDS) can be used for the improvement of sheridan baker thesis machine bioavailability of the drug. Social Thesis! In the preparation of this system containing with telmisartain as active pharmaceutical ingredient. To increase bioavailability solubility of this drug. Due to poor solubility of telmisartain it cannot be formulate in essays in america, the oral drug delivery system. But with the help of LSEDDS it’s possible to give telmisartain via oral drug delivery system.

After the complete study of LSEDDS we conclude that the system was very useful for the active drug molecules having poor solubility. 1. Yamamoto, J. and thesis H. Tanaka, prepare neomatic phase in the liquid micro-emulsion. Nature (London), 2001. 409(6818): p. 321-325. 2. Porter, C.J.H., N.L. Trevaskis, and W.N. Charman, Lipids and lipid-based formulations: for the optimization of ourselves essay drug delivery by oral route lipophilic drug. Nature Reviews Drug Discovery, 2007. 6(3): p. 231-248.

3. Networking! Humberstone, A.J. and W.N. Charman, the oral drug delivery of poorly water soluble drugs. By forming a lipid based drug delivery system Advanced Drug Delivery Reviews, 1997. 25(1): p. 103-128. 4. Kommuru, T.R., et al., Self-emulsifying drug delivery systems (SEDDS) of essay coenzyme Q10: formulation development and bioavailability assessment By forming a lipid based drug delivery system Advanced Drug Delivery. Int J Pharm, 2001. 212(2): p. 233-46. 5. Neslihan Gursoy, R. and social networking thesis papers S. Benita, Self-emulsifying drug delivery systems (SEDDS) for improved bioavability of baylor essay poorly water soluble drug. Biomedicine Pharmacotherapy, 2004. 58(3): p. 173-182.

6. Hauss, D.J., et al., prepare lipid based drug delivery system for poorly water soluble drug LTB4 inhibito to enhance there solubility as well as bioavability. Journal of Pharmaceutical Sciences, 1998. 87(2): p. 164-169. 7. Gao, P., et al., Development of social thesis a super saturable SEDDS (S-SEDDS) formulation of paclitaxel with improved there solubility that can enhance the bioavability of poorlt water soluble drug. Journal of Pharmaceutical Sciences, 2003. 92(12): p. 2386-2398. 8. Patil Pradeep, R., et al., Bioavailability assessment of ketoprofen incorporated in gelled self-emulsifying formulation to improve the bioavability by baylor university essay using lipid based drug delivery systemAAPS PharmSciTech, 2005. 6(1): p. E9-13. 9. Kang, B.K., et al., Development of social networking self-microemulsifying drug delivery system(SMEDDS) for improve the bioavability by using lipid based drug delivery. International Journal of hormone research paper Pharmaceutics, 2004. 274(1-2): p. 65-73.

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Nkemnele, formulation and university admissions evaluation SEDDS using a biodegradable homolipid from Capra hircus. Social! International Journal of Pharmaceutics, 2005. 304(1-2): p. 4-10. 13. Djordjevic, L., M. Primorac, and M. Stupar, In vitro release of diclofenac diethylamide by using a lipid based microemulsion system. International Journal of hormone research paper Pharmaceutics, 2005. Networking Papers! 296(1-2): p. 73-79. 14. Agatonovic-Kustrin, S., et al., Prediction of a Stable Microemulsion Formulation for the Oral Delivery of a Combination of Antitubercular Drugs Using ANN Methodology. Pharmaceutical Research, 2003.

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J. Pharm., 2009. 365: p. 136-142. 17. Holm, R., I.H.M. Jensen, and J. Sonnergaard, Optimization of thesis papers selfmicroemulsifying drug delivery systems using a d-optimal design and the desirability function. Drug. Dev. Ind.

Pharm., 2006. 32: p. 1025-1032. 18. Porter, C.J.H., N.L. Trevaskis, and W.N. Charman, Lipids and lipid-based formulations: optimizing the oral delivery of sheridan baker thesis lipophilic drugs. Nat. Social Papers! Rev. Drug Discov., 2007. 6: p. 231-248.

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2004; 270(1-2): 109-18. 21. O’Driscoll CM and Griffin BT. Biopharmaceutical challenges associated with drugs with low aqueous solubility–the potential impact of lipid-based formulations. Adv Drug Deliv Rev. 2008; 60(6): 617-24. 22. Koga K, Kusawake Y, Ito Y, Sugioka N, Shibata N and Takada K. Ourselves Essay! Enhancing mechanism of Labrasol on intestinal membrane permeability of the hydrophilic drug gentamicin sulfate. Eur J Pharm Biopharm. 2006; 64(1): 82-91. 23.

Sha X, Yan G, Wu Y, Li J and Fang X. Social Networking Papers! Effect of level 1 english self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Networking Thesis Papers! Eur J Pharm Sci. 2005; 24(5): 477-86. 24. Sha XY and Fang XL. Effect of self-microemulsifying system on cell tight junctions. Yao Xue Xue Bao. 2006; 41(1): 30-5. 25.

Yang S, Gursoy RN, Lambert G and Benita S. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharm Res. 2004; 21(2): 261-70. 26. Constantinides PP and Wasan KM. Lipid formulation strategies for enhancing intestinal transport and politics in indian uni absorption of papers P-glycoprotein (P-gp) substrate drugs: in vitro/in vivo case studies. J Pharm Sci. 2007; 96(2): 235-48. 27. Charman WN, Rogge MC, Boddy AW and Berger BM.

Effect of food and sheridan thesis a monoglyceride emulsion formulation on danazol bioavailability. Social! J. Clin. Pharmacol. 1993; 33: 381’6. 28. Welling PG. Effects of food on drug absorption. Baylor University! Ann. Rev. Nutr. 1996; 16 383’415.

29. Araya H, Tomita M and Hayashi M. The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Int J Pharm. 2005; 305(1-2): 61-74. 30. Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK and Ali M. Development and social networking papers bioavailability assessment of sheridan ramipril nanoemulsion formulation. Eur J Pharm Biopharm. 2007; 66(2): 227-43. 31.

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50. . Yi T., Wan J., Xu H. Yang X. (2008), A new solid self-microemulsifying formulation prepared by spray-drying to improve the essays on injustice in america oral bioavailability of poorly water soluble drugs, European Journal of Pharmaceutics and Biopharmaceutics, 70: 439-444. 51. Abdalla A., Klein S., Mi??i??der K. (2008), A new self-emulsifying drug delivery system (SEDDS) for networking papers poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets, European Journal of Pharmaceutical Sciences, 35: 457-464. 52. Thesis In Indian! Lu J. L., Wang J. C., Zhao S. X., Liu X. Networking Thesis! Y., Zhao H., Zhang X., Zhou S. Admissions! F., Zhang Q. (2008), Self-microemulsifying drug delivery system (SMEDDS) improves anticancer effect of oral 9-nitrocamptothecin on human cancer xenografts in nude mice, European Journal of Pharmaceutics and Biopharmaceutics, 69: 899-907.

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Boonme P., Krauel K., Graf A., Rades T., Junyaprasert V. B. (2006), Characterization of Microemulsion Structures in the Pseudoternary Phase Diagram of Isopropyl Palmitate/Water/Brij 97:1-Butanol, AAPS PharmSciTech, 7(2) Article 45: E1-E6. 59. Agarwal V., Siddiqui A., Ali H., Nazzal S. (2006), Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS), International Journal of Pharmaceutics, 366: 44-52. 60. Wu W., Wang Y., Que L. (2006), Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system, European Journal of networking papers Pharmaceutics and plant research paper Biopharmaceutics, 63: 288-294.

61. Itoa Y., Kusawake T., Ishida M., Tawa R., Shibata N., Takada K. (2005), Oral solid gentamicin preparation using emulsifier and adsorbent, Journal of papers Controlled Release, 105: 23-31. 62. Baker Thesis Machine! Sha X., Yan G., Wu Y., Li J., Fang X. (2005), Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells, European Journal of Pharmaceutical Sciences, 24: 477-486. 63.

Subramanian N., Ray S., Ghosal S. K., Bhadra R., Moulik S. P. (2004), Formulation Design of Self-Microemulsifying Drug Delivery Systems for Improved Oral Bioavailability of Celecoxib, Biol. Pharm. Bull., 27(12): 1993-1999. 64. Kang B. K., Lee J. S., Chon S. K., Jeong S. Y., Yuk S. H., Khang G, Lee H. Social Thesis Papers! B., Cho S. H. Plant Hormone Paper! (2004), Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in social papers, beagle dogs, International Journal of Pharmaceutics, 274: 65-73. 65. Patil P., Joshi P., Paradkar A. (2004), Effect of Formulation Variables on Preparation and Evaluation of Gelled Self-emulsifying Drug Delivery System (SEDDS) of Ketoprofen, AAPS PharmSciTech, 5(3) Article 42: 1-8. 66. Holm R., Christopher J. H. P., Glenn A. E., Anette M., Henning G. K. , Charman W. Essay! N. (2003), Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in papers, self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides, European Journal of baylor essay Pharmaceutical Sciences, 20: 91-97. 67. Itoh K., Tozuka Y., Oguchi T., Yamamoto K. (2002), Improvement of physicochemical properties of thesis N-4472 part I formulation design by using self-microemulsifying system, International Journal of Pharmaceutics, 238: 153-160.

68. Agarwal V., Siddiqui A., Ali H., Nazzal S. (2000), Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS), International Journal of plant Pharmaceutics, 366: 44-52. 69. Kim H. J., Yoon K. A., Hahn M., Park E. S., Chi S. C., (2000), Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone, Drug Dev Ind Pharm., 26(5): 523-529. 70. Chen G. L., Lee F. Y. Networking Thesis Papers! (1996), Validation of our daughters ourselves botanical method for Verapamil by networking thesis high performance liquid chromatography, J Med Sci, 17(1): 16-23. 71.

Shah N.H., Carvajal M.T., Patel C.I., Infeld M.H., Malick A.W. (1994), Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for politics improving in vitro dissolution and oral absorption of lipophilic drugs, International Journal of social Pharmaceutics, 106: 15-23. 74. Indian pharmacopeia. 75. British pharmacopeia. 76. Bhagwat durgachara, D. Baylor University Admissions Essay! souza I. development of social self micro emulsifying drug delivery system.to inhance dissolution rate of telmisartain, IJDDR 2012,02(04);398-407. 77. Gaikwad G, Godbole M, potnos V, Daud A. Formulation and evaluation of self emulcifying drug delivery system of ncea level exemplars orlistat, Americal Journal Of Pharmtech Research 2012; 2 (6): 297-31. Search our thousands of essays:

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